Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
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Historia sobre el papel de las hormonas y los anticonceptivos en el lupus historic view on the role of hormones and hormonal contraceptives in pathogenesis of systemic lupus
Edgar Peñaranda-Parada,Federico Rondón-Herrera,José Félix Restrepo-Suárez,Gerardo Quintana,Antonio Iglesias-Gamarra +4 more
TL;DR: In this article, the authors reviewed the literature on lupus pathogenesis from the beginning of the 20th century until its end and the importance of discoveries and merits of different investigators.
Journal ArticleDOI
Systemic lupus: basic mechanisms and prospects for specific immunotherapy
TL;DR: This work localized the critical peptide autoepitopes for lupus nephritis-inducing Th cells in the core histones of nucleosomes, at amino acid positions 10–33 of H2B, and 16–39 and 71–94 of H4.
Book ChapterDOI
Grundsätzliches zur innerlichen Behandlung von Autoimmunerkrankungen
TL;DR: In this article, the authors propose a method to werten klinisch noch atiopathogenetisch, noch therapeutisch scharf gefast the Begriff „Autoimmunerkrankung“.
Book ChapterDOI
Viruses, Genetics and Autoimmunity
TL;DR: Patients with autoimmune disease are frequently characterized by an immunologic imbalance in which T cell activities are depressed and B cells are polyclonally activated.
References
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Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.