Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
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Journal ArticleDOI
Prostaglandins and Cyclic Nucleotides in the Chédiak-Higashi Syndrome and Experimental Systemic Lupus Erythematosus
TL;DR: Early results in approximately 6 CH patients indicate that vitamin C therapy restores leukocytes function and prevents recurrent infections, and ascorbic acid increases human leukocyte cGMP levels in vitro.
Journal ArticleDOI
Altered immune complex-induced prostaglandin production in human and murine lupus.
TL;DR: It is hypothesized that defective Fc receptor function on monocytes of patients with SLE prevent IC-induced production of normal amounts of PGE.
Book ChapterDOI
[36] Murine lupus
TL;DR: In mice with lupus nephritis qualitative changes in anti-DNA antibodies occur, such as IgG switch and increased cationic charge, to render these antibodies pathogenic.
Journal ArticleDOI
Double-stranded RNA antibodies in systemic lupus erythematosus.
P Davis,P Cunnington,G R Hughes +2 more
TL;DR: High titres of antibody to ds viral RNA were found almost exclusively in SLE, diagnostically more specific SLE than those directed against artificial polynucleotides, poly I:C and poly A:U.
References
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Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.