Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
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Book ChapterDOI
Immunity and Tolerance to Synthetic Polynucleotides in New Zealand Mice
Norman Talal,Alfred D. Steinberg +1 more
TL;DR: The laboratory has been studying the pathogenesis of the autoimmune disorder systemic lupus erythematosus as it occurs in humans and in the inbred New Zealand mice, and three factors contribute to this disorder.
Journal ArticleDOI
Incidence of Hepatitis Associated Antigen HAA and Homologous Antibody in Patients with Rheumatoid Arthritis
TL;DR: The authors emphasize as suggestive the hypothesis that the characteristic histopathological alterations of rheumatoid arthritis may be mediated by an immunological reaction toward an infectious agent other than HAA, but operating through mechanisms similar to those of HAA in polyarteritis nodosa.
Journal ArticleDOI
Relationship between anti-DNA antibody and anti-lymphocyte antibody in active and inactive SLE sera
TL;DR: Significant correlations between anti-single stranded (ss) DNA antibody and anti-lymphocyte antibody (ALA) were found in the sera of patients with active systemic lupus erythematosus (SLE) and inactive SLE, but there was no significant correlation betweenAnti-double stranded (ds) DNA antibodies and ALA.
Systemic lupus erythematosus in libyans: an appraisal of the 1982 revised criteria for classification
TL;DR: Of the various immunological investigations that were conducted and compared, anti-dsDNA antibody test exhibited the highest specificity for differential diagnosis of SLE and is recommended in all cases wherever clinically appropriate regardless of the presence of antinuclear antibody.
References
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Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.