Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
TLDR
The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TL;DR: Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Benzodiazepine receptors mediate regional bloodflowchanges in theliving humanbrain
TL;DR: In this paper, the effects of a high affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography were studied.
References
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Journal ArticleDOI
Thiopental Inhibits Increases in [Ca2+]i Induced by Membrane Depolarization, NMDA Receptor Activation, and Ischemia in Rat Hippocampal and Cortical Slices
Ren-Zhi Zhan,Naoshi Fujiwara,Hiroshi Endoh,Tomohiro Yamakura,Kiichiro Taga,Satoru Fukuda,Koki Shimoji +6 more
TL;DR: The results indicate that thiopental attenuates ischemia‐induced [Ca2+]i increases in the hippocampus and cortex in vitro, probably because of its inhibition of both voltage‐gated calcium channels and NMDA receptors.
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Effects of pre- and postischemic administration of thiopental on transmitter amino acid release and histologic outcome in gerbils.
TL;DR: Thiopental helps protect the brain from ischemia, although treatment with this agent after ischemIA requires a larger dose than that before ischemía.
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Cerebral vasomotor responses during oxygen inhalation. Results in normal aging and dementia.
TL;DR: Testing cerebral vasoconstrictor responses by 100% oxygen inhalation is helpful for differentiating senile dementia of Alzheimer's type from multi-infarct dementia.
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The effect of nitrous oxide on cerebrovascular reactivity to carbon dioxide in children during propofol anesthesia.
TL;DR: N2O does not affect CCO2R during propofol anesthesia in children, and the combination of N2O with prop ofolesthesia in children would seem suitable when preservation of C CO2R is required.
Journal ArticleDOI
Transcranial Doppler ultrasound study of the effects of nitrous oxide on cerebral autoregulation during neurosurgical anesthesia: a randomized controlled trial
Domenico Gerardo Iacopino,Alfredo Conti,Calogero Battaglia,Clotilde Siliotti,T. Lucanto,Letterio B. Santamaria,Francesco Tomasello +6 more
TL;DR: The increase in CBF and the reduction in autoregulatory indices suggest caution in using N2O during sevoflurane anesthesia, especially in patients with reduced autoreGulatory reserve and during neurosurgical interventions.