Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
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The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TL;DR: Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Benzodiazepine receptors mediate regional bloodflowchanges in theliving humanbrain
TL;DR: In this paper, the effects of a high affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography were studied.
References
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Neuropsychiatric Complications after Cardiopulmonary Bypass: Cerebral Protection by a Barbiturate
TL;DR: The authors prospectively investigated the ability of thiopental to decrease neuropsychiatric complications as a consequence of openventricle operations requiring cardiopulmonary bypass and randomly assigned patients received sufficient thiopents to maintain electroencephalographic silence.
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Mortality of Shipham residents: 40-year follow-up.
TL;DR: In this paper, the 1939 populations of Shipham, a village in Somerset with high soil-cadmium levels, and a nearby control village have been followed for 40 years, and the mortality rates were compared with those for England and Wales.
Journal Article
Changes in regional cerebral blood flow during brain maturation in children and adolescents.
Catherine Chiron,Claude Raynaud,Bernard Maziere,Monica Zilbovicius,Louis Laflamme,Marie-Cécile Masure,Olivier Dulac,Michel H. Bourguignon,André Syrota +8 more
TL;DR: Cognitive development of the child seems to be related to changes in blood flow of the corresponding brain regions, which was studied by SPECT using 133Xe in 42 children considered as neurologically normal.
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Mannitol causes compensatory cerebral vasoconstriction and vasodilation in response to blood viscosity changes.
TL;DR: An alternative explanation is offered for the effect of mannitol on ICP, the time course of ICP changes, "rebound effect," and the absence of influence on CBF, all with one mechanism.
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Effect of mannitol on ICP and CBF and correlation with pressure autoregulation in severely head-injured patients
TL;DR: The changes in intracranial pressure (ICP) and cerebral blood flow (CBF) after mannitol administration in a group of severely head-injured patients with intact or defective autoregulation is described.