Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
TLDR
The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
Citations
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TL;DR: Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Benzodiazepine receptors mediate regional bloodflowchanges in theliving humanbrain
TL;DR: In this paper, the effects of a high affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography were studied.
References
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Journal ArticleDOI
Blood Flow Distribution in the Normal Human Preterm Brain
Klaus Børch,Gorm Greisen +1 more
TL;DR: In this paper, the authors measured regional cerebral blood flow (rCBF) in preterm infants using a mobile brain dedicated fast-rotating four-head multidetector system specially designed for neonatal studies.
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Nitrous Oxide Markedly Increases Cerebral Cortical Metabolic Rate and Blood Flow in the Goat
TL;DR: N2O (at least in goats) is associated with a marked cerebral cortical “activation” and changes in cerebral O2 metabolism (CMRO2) and total and regional CBF (rCBF) are attributed solely to the presence of N2O.
Journal ArticleDOI
Cerebrovascular tone rather than intracranial pressure determines the effective downstream pressure of the cerebral circulation in the absence of intracranial hypertension.
Andreas Weyland,Wolfgang Buhre,Stephan Grund,Hans Ludwig,Stephan Kazmaier,Wolfgang Weyland,Hans Sonntag +6 more
TL;DR: The results demonstrate that, in the absence of intracranial hypertension, intrac Cranial pressure does not necessarily represent the effective downstream pressure of the cerebral circulation, and suggests a modified model ofThe cerebral circulation based on the existence of two Starling resistors in a series connection.
Journal ArticleDOI
Focal cerebral ischemia during anesthesia with etomidate, isoflurane, or thiopental: a comparison of the extent of cerebral injury.
TL;DR: It is speculated that the apparently detrimental effect of etomidate may be the result of the binding of nitric oxide of cerebral endothelial origin by the iron component of free hemoglobin, which is consistent with a protective effect by barbiturates.
Journal ArticleDOI
Critical closing pressure in cerebrovascular circulation
Marek Czosnyka,Piotr Smielewski,Stefan K. Piechnik,Pippa G. Al-Rawi,Peter J. Kirkpatrick,Basil F. Matta,John D. Pickard +6 more
TL;DR: Critical closing pressure, although sensitive to variations in ICP and CPP, cannot be used as an accurate estimator of these modalities with acceptable confidence intervals.