Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
TLDR
The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TL;DR: Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Benzodiazepine receptors mediate regional bloodflowchanges in theliving humanbrain
TL;DR: In this paper, the effects of a high affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography were studied.
References
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Journal ArticleDOI
Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity
TL;DR: Before the modulatory effects of hyperoxia can be used for diagnosis, to predict prognosis or to direct therapy, a more detailed analysis and understanding of the physiological concepts behind this modulation are required, as are the limitations of the measurement tools used to define the modulation.
Journal ArticleDOI
Effects of sevoflurane with and without nitrous oxide on human cerebral circulation. Transcranial Doppler study.
TL;DR: Evaluating the effects of sevoflurane with and without nitrous oxide on human middle cerebral artery flow velocity, cerebrovascular carbon dioxide reactivity, and autoregulation compared with the awake state using transcranial Doppler ultrasonography found that 1.2 MAC reduced Vmca compared withThe awake condition, whereas the addition ofNitrous oxide caused VmCA to increase toward the values obtained in the awake condition.
Journal ArticleDOI
Cerebral oxygenation in patients after severe head injury: monitoring and effects of arterial hyperoxia on cerebral blood flow, metabolism and intracranial pressure.
M. Menzel,Egon M.R. Doppenberg,A. Zauner,Jens Soukup,Michael Reinert,Tobias Clausen,Paula B. Brockenbrough,Ross Bullock +7 more
TL;DR: Monitoring PtiO2 after SHI provides valuable information about cerebral oxygenation and substrate delivery and inversely correlated with outcome (P < .01).
Journal ArticleDOI
Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
William E. Hoffman,Dale A. Pelligrino,Christian Werner,Eberhard Kochs,Ronald F. Albrecht,Jochem Schulte am Esch +5 more
TL;DR: It is suggested that ketamine improves neurologic outcome from incomplete cerebral ischemia by a mechanism related to a decrease in plasma catecholamine activity.