Journal ArticleDOI
In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine
Quan Le Tran,Yasuhiro Tezuka,Jun-ya Ueda,Nhan Trung Nguyen,Yukiko Maruyama,Khurshida Begum,Hye Sook Kim,Yusuke Wataya,Qui Kim Tran,Shigetoshi Kadota +9 more
TLDR
Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC(50) values less than 10 microg/ml.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2003-06-01. It has received 101 citations till now. The article focuses on the topics: Coscinium fenestratum.read more
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Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
TL;DR: The liver and intestinal bacteria participate in the metabolism and disposition of Ber in vivo, and the intestinal flora played a significant role in the enterohepatic circulation of metabolites.
Journal ArticleDOI
Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage Form for Oral Delivery
Sunil Kumar Battu,Michael A. Repka,Sindhuri Maddineni,Amar G. Chittiboyina,Mitchell A. Avery,Soumyajit Majumdar +5 more
TL;DR: The physicochemical characteristics of berberine chloride and the complexation of drug with 2-hydroxypropyl-β-cyclodextrin (HPβCD) were evaluated and the feasibility of developing an oral solution dosage form of the drug was demonstrated.
Journal ArticleDOI
Plant alkaloids as drug leads for Alzheimer's disease.
TL;DR: It remains promising that an alkaloid drug candidate could significantly affect the progression of AD in addition to providing symptomatic relief.
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The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
Luiz Augusto Basso,Luiz Hildebrando Pereira da Silva,Arthur Germano Fett-Neto,Walter Filgueira de Azevedo Junior,Ícaro de Souza Moreira,Mario Sergio Palma,João B. Calixto,Spartaco Astolfi Filho,Ricardo Ribeiro dos Santos,Milena Botelho Pereira Soares,Diógenes Santiago Santos +10 more
TL;DR: The present review describes some strategies to search for natural compounds, whose choice can be based on ethnobotanical and chemotaxonomical studies, and screen for their ability to bind to immobilized drug targets and to inhibit their activities.
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Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research.
TL;DR: This review summarizes recent research on the neuropharmacological and pharmacokinetic properties of berberine, an isoquinoline alkaloid extracted from Coptidis rhizoma.
References
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Medical need, scientific opportunity and the drive for antimalarial drugs
TL;DR: Mechanisms of partnering with industry have been established to overcome this obstacle and to open up and build on scientific opportunities for improved chemotherapy in the future.
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In vitro screening of Indian medicinal plants for antiplasmodial activity.
Henrik Toft Simonsen,Jesper Brændegaard Nordskjold,Ulla Wagner Smitt,Ulf Nyman,Pushpangadan Palpu,Prabhakar Joshi,George Varughese +6 more
TL;DR: Plants traditionally used in India to treat fever or malaria were examined in vitro for antiplasmodial properties against Plasmodium falciparum, and five species seems to be of special interest for further antimalarial studies.
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Antimalarial activity of extracts of Malaysian medicinal plants.
TL;DR: In vitro and in vivo studies revealed that Malaysian medicinal plants, Piper sarmentosum, Andrographis paniculata and Tinospora crispa produced considerable antimalarial effects and chloroform extract in vitro did show better effect than the methanol extract.
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Antiproliferative activity of Vietnamese medicinal plants.
Jun-ya Ueda,Yasuhiro Tezuka,Arjun H. Banskota,Quan Le Tran,Qui Kim Tran,Yuko Harimaya,Ikuo Saiki,Shigetoshi Kadota +7 more
TL;DR: Characteristic morphological change and DNA fragmentation indicated the antiproliferative activity to be due to the induction of apoptosis.
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Plants as Sources of Antimalarial Drugs Part. 1. In vitro Test Method for the Evaluation of Crude Extracts from Plants
TL;DR: An IN VITRO antimalarial test, utilising the inhibition of uptake of [G- 3 H]-hypoxanthine into PLASMODIUM FALCIPARUM cultured in human blood, has been used to assess the activity of crude extracts of ARTEMISIA ANNUA and A. VULGARIS.