In vitro approaches to assess the hazard of nanomaterials
Barbara Drasler,Phil Sayre,Klaus Günter Steinhäuser,Alke Petri-Fink,Barbara Rothen-Rutishauser +4 more
TLDR
An improved comprehension of the approaches with its limitations used for nanomaterials' hazard assessment in vitro will improve the interpretation of the existing nanotoxicological data as well as underline the basic principles in understanding interactions of engineered nanomMaterials at a cellular level.About:
This article is published in NanoImpact.The article was published on 2017-10-01 and is currently open access. It has received 167 citations till now.read more
Citations
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Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health.
Anthony Hardy,Diane Benford,Thorhallur I. Halldorsson,Michael J. Jeger,Helle Katrine Knutsen,Simon J. More,Hanspeter Naegeli,Hubert Noteborn,Colin Ockleford,Antonia Ricci,Guido Rychen,Josef Rudolf Schlatter,Vittorio Silano,Roland Solecki,Dominique Turck,Maged Younes,Qasim Chaudhry,Francesco Cubadda,David Michael Gott,Agnes G. Oomen,Stefan Weigel,Melpo Karamitrou,Reinhilde Schoonjans,Alicja Mortensen +23 more
TL;DR: The European Food Safety Authority has produced this Guidance on human and animal health aspects of the risk assessment of nanoscience and nanotechnology applications in the food and feed chain, which covers the application areas within EFSA's remit.
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Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
Michelle Hesler,Leonie Aengenheister,Bernhard Ellinger,Roland Drexel,Susanne Straskraba,Carsten Jost,Sylvia Wagner,Florian Meier,Hagen von Briesen,Claudia Büchel,Peter Wick,Tina Buerki-Thurnherr,Yvonne Kohl +12 more
TL;DR: This study investigated the transport and effects of 50 nm and 0.5 μm COOH-modified polystyrene (PS) particles, as representatives for NP and MP, in different biological models in vitro, and identified them as weak embryotoxic and non-genotoxic.
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Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data.
TL;DR: An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects.
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Green Nanotechnology: Advancement in Phytoformulation Research.
TL;DR: The potential of the utilization of plant extracts in the advancement of nanotechnology is discussed, which significantly contributes to environmental sustainability through the production of nanomaterials and nanoproducts, without causing harm to human health or the environment.
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In vivo effects: Methodologies and biokinetics of inhaled nanomaterials
TL;DR: The suggested grouping and extrapolation framework presented in this paper could be pivotal in leveraging subchronic inhalation data with data from alternative test methods, thus leading to more efficient, cost-effective, and – in the long run – animal and cost saving methods to obtain needed input data for regulatory use.
References
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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
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Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
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Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
Tommy Cedervall,Iseult Lynch,Stina Lindman,Tord Berggård,Eva Thulin,Hanna Nilsson,Kenneth A. Dawson,Sara Linse +7 more
TL;DR: The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.
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Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Martin Lundqvist,Johannes Stigler,Giuliano Elia,Iseult Lynch,Tommy Cedervall,Kenneth A. Dawson +5 more
TL;DR: The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.