In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography
Ik-Kyung Jang,Guillermo J. Tearney,Briain D. MacNeill,Masamichi Takano,Fabian Moselewski,Nicusor Iftima,Milen Shishkov,Stuart L. Houser,H. Thomas Aretz,Elkan F. Halpern,Brett E. Bouma +10 more
TLDR
OCT is a safe and effective modality for characterizing coronary atherosclerotic plaques in vivo and thin-cap fibroatheroma was more frequently observed in patients with AMI or ACS than SAP.Abstract:
Background— The current understanding of the pathophysiology of coronary artery disease is based largely on postmortem studies. Optical coherence tomography (OCT) is a high-resolution (≈10 μm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo. Methods and Results— Patients undergoing cardiac catheterization were enrolled and categorized according to their clinical presentation: recent acute myocardial infarction (AMI), acute coronary syndromes (ACS) constituting non-ST-segment elevation AMI and unstable angina, or stable angina pectoris (SAP). OCT imaging was performed with a 3.2F catheter. Two observers independently analyzed the images using the previously validated criteria for plaque characterization. Of 69 patients enrolled, 57 patients (20 with AMI, 20 with ACS, and 17 with SAP) had analyzable images. In the AMI, ACS, and SAP groups, lipid-rich plaque (defined by lipid occupying ≥2 quadrants of the cross-sectional area) was observed in 90%, 75%, an...read more
Citations
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Journal ArticleDOI
Concept of Vulnerable/Unstable Plaque
TL;DR: Advancing the field will require establishing relevant translational animal models that produce vulnerable plaques at risk for rupture and further testing of these modalities in large prospective clinical trials, including optical coherence tomography, high-resolution MRI, molecular biomarkers, and other techniques.
Journal ArticleDOI
Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes.
Sadako Motoyama,Takeshi Kondo,Masayoshi Sarai,Atsushi Sugiura,Hiroto Harigaya,Takahisa Sato,Kaori Inoue,Masanori Okumura,Junichi Ishii,Hirofumi Anno,Renu Virmani,Yukio Ozaki,Hitoshi Hishida,Jagat Narula +13 more
TL;DR: The CT characteristics of plaques associated with ACS include positive vascular remodeling, low plaque density, and spotty calcification, and it is logical to presume that plaques vulnerable to rupture harbor similar characteristics.
Journal ArticleDOI
Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy.
Takashi Kubo,Toshio Imanishi,Shigeho Takarada,Akio Kuroi,Satoshi Ueno,Takashi Yamano,Takashi Tanimoto,Yoshiki Matsuo,Takashi Masho,Hironori Kitabata,Kazushi Tsuda,Yoshiaki Tomobuchi,Takashi Akasaka +12 more
TL;DR: Optical coherence tomography is a feasible imaging modality in patients with AMI and allows us to identify not only plaque rupture, but also fibrous cap erosion, intracoronary thrombus, and TCFA in vivo more frequently compared with conventional imaging techniques.
Journal ArticleDOI
Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: Physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis
Francesco Prati,Evelyn Regar,Gary S. Mintz,Eloisa Arbustini,Carlo Di Mario,Ik-Kyung Jang,Takashi Akasaka,Marco A. Costa,Giulio Guagliumi,Eberhard Grube,Yukio Ozaki,Fausto J. Pinto,Patrick W. Serruys +12 more
TL;DR: The aim of the present Expert Review Document is to address the methodology, terminology and clinical applications of OCT for qualitative and quantitative assessment of coronary arteries and atherosclerosis.
Journal ArticleDOI
Assessment of Coronary Arterial Plaque by Optical Coherence Tomography
Teruyoshi Kume,Takashi Akasaka,Takahiro Kawamoto,Nozomi Watanabe,Eiji Toyota,Yoji Neishi,Renan Sukmawan,Yoshito Sadahira,Kiyoshi Yoshida +8 more
TL;DR: In conclusion, the high resolution of OCT permitted evaluation of lipid-rich plaques more accurately than IVUS, and OCT had a higher sensitivity for characterizing lipid- rich plaques than IV US.
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