Characterization of Human Atherosclerosis by Optical Coherence Tomography
Hiroshi Yabushita,Brett E. Bouma,Stuart L. Houser,H. Thomas Aretz,Ik-Kyung Jang,Kelly Schlendorf,Christopher R. Kauffman,Milen Shishkov,Dong-Heon Kang,Elkan F. Halpern,Guillermo J. Tearney +10 more
TLDR
Objective OCT criteria are highly sensitive and specific for characterizing different types of atherosclerotic plaques in vitro and will provide a basis for the interpretation of intracoronary OCT images obtained from patients.Abstract:
Background— High-resolution visualization of atherosclerotic plaque morphology may be essential for identifying coronary plaques that cause acute coronary events. Optical coherence tomography (OCT) is an intravascular imaging modality capable of providing cross-sectional images of tissue with a resolution of 10 μm. To date, OCT imaging has not been investigated in sufficient detail to assess its accuracy for characterizing atherosclerotic plaques. The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro. Methods and Results— OCT images of 357 (diseased) atherosclerotic arterial segments obtained at autopsy were correlated with histology. OCT image criteria for 3 types of plaque were formulated by analysis of a subset (n=50) of arterial segments. OCT images of fibrous plaques were characterized by homogeneous, signal-rich regions; fibrocalcific plaques by well-delineated, signal-poor regions with sharp borders; and lipid-rich plaques by signal...read more
Citations
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In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Brett E. Bouma,Stephen A. Boppart,Costas Pitris,James F. Southern,James G. Fujimoto +6 more
TL;DR: In this article, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, which was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal ArticleDOI
In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography
Ik-Kyung Jang,Guillermo J. Tearney,Briain D. MacNeill,Masamichi Takano,Fabian Moselewski,Nicusor Iftima,Milen Shishkov,Stuart L. Houser,H. Thomas Aretz,Elkan F. Halpern,Brett E. Bouma +10 more
TL;DR: OCT is a safe and effective modality for characterizing coronary atherosclerotic plaques in vivo and thin-cap fibroatheroma was more frequently observed in patients with AMI or ACS than SAP.
Journal ArticleDOI
Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy.
Takashi Kubo,Toshio Imanishi,Shigeho Takarada,Akio Kuroi,Satoshi Ueno,Takashi Yamano,Takashi Tanimoto,Yoshiki Matsuo,Takashi Masho,Hironori Kitabata,Kazushi Tsuda,Yoshiaki Tomobuchi,Takashi Akasaka +12 more
TL;DR: Optical coherence tomography is a feasible imaging modality in patients with AMI and allows us to identify not only plaque rupture, but also fibrous cap erosion, intracoronary thrombus, and TCFA in vivo more frequently compared with conventional imaging techniques.
Journal ArticleDOI
Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: Physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis
Francesco Prati,Evelyn Regar,Gary S. Mintz,Eloisa Arbustini,Carlo Di Mario,Ik-Kyung Jang,Takashi Akasaka,Marco A. Costa,Giulio Guagliumi,Eberhard Grube,Yukio Ozaki,Fausto J. Pinto,Patrick W. Serruys +12 more
TL;DR: The aim of the present Expert Review Document is to address the methodology, terminology and clinical applications of OCT for qualitative and quantitative assessment of coronary arteries and atherosclerosis.
Journal ArticleDOI
Intracoronary Optical Coherence Tomography: A Comprehensive Review: Clinical and Research Applications
TL;DR: This comprehensive review will assist practicing interventional cardiologists in understanding the technical aspects of OCT based upon the physics of light and will also highlight the emerging research and clinical applications of OCT.
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