In vivo recordings of brain activity using organic transistors
Dion Khodagholy,Thomas Doublet,Pascale P. Quilichini,Pascale P. Quilichini,M. Gurfinkel,Pierre Leleux,Antoine Ghestem,Antoine Ghestem,Esma Ismailova,Thierry Hervé,Sébastien Sanaur,Christophe Bernard,Christophe Bernard,George G. Malliaras +13 more
TLDR
The engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain with superior signal-to-noise ratio is demonstrated.Abstract:
In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.read more
Citations
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Skin electronics from scalable fabrication of an intrinsically stretchable transistor array.
Sihong Wang,Jie Xu,Weichen Wang,Ging-Ji Nathan Wang,Reza Rastak,Francisco Molina-Lopez,Jong Won Chung,Jong Won Chung,Simiao Niu,Vivian R. Feig,Jeffery Lopez,Ting Lei,Soon-Ki Kwon,Yeongin Kim,Amir M. Foudeh,Anatol Ehrlich,Andrea Gasperini,Youngjun Yun,Youngjun Yun,Boris Murmann,Jeffery B.-H. Tok,Zhenan Bao +21 more
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TL;DR: Materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address technical challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate are described.
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References
More filters
Journal ArticleDOI
Neuronal Oscillations in Cortical Networks
György Buzsáki,Andreas Draguhn +1 more
TL;DR: Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.
Book
Rhythms of the brain
TL;DR: The brain's default state: self-organized oscillations in rest and sleep, and perturbation of the default patterns by experience.
Journal ArticleDOI
The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes
TL;DR: High-density recordings of field activity in animals and subdural grid recordings in humans can provide insight into the cooperative behaviour of neurons, their average synaptic input and their spiking output, and can increase the understanding of how these processes contribute to the extracellular signal.
Journal ArticleDOI
High gamma power is phase-locked to theta oscillations in human neocortex.
Ryan T. Canolty,Erik Edwards,Erik Edwards,Sarang S. Dalal,Maryam Soltani,Maryam Soltani,Srikantan S. Nagarajan,Heidi E. Kirsch,Mitchel S. Berger,Nicholas M. Barbaro,Robert T. Knight +10 more
TL;DR: The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans.
Journal ArticleDOI
Place units in the hippocampus of the freely moving rat
TL;DR: The results suggest that place units were not responding to a simple sensory stimulus nor to a specific motor behavior, and are interpreted as strong support for the cognitive map theory of hippocampal function.