Journal ArticleDOI
Increased nitric oxide in exhaled air of asthmatic patients
Sergei A. Kharitonov,Deborah H Yates,Richard A. Robbins,Peter J. Barnes,R B Logan-Sinclair,E.A. Shinebourne +5 more
Reads0
Chats0
TLDR
In this paper, the authors measured the NO in patients with asthma using a slow vital capacity manoeuvre and an adapted chemiluminescence analyser and found that NO was detectable in exhaled air of 67 control subjects (mean peak concentration 80·2 [SE4·1] ppb) and was significantly reduced by inhaling the specific NO synthase inhibitor N G -monomethyl-Larginine.About:
This article is published in The Lancet.The article was published on 1994-01-15. It has received 1444 citations till now. The article focuses on the topics: Exhaled nitric oxide & Nitric oxide.read more
Citations
More filters
Journal ArticleDOI
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
Peter J. Barnes,Michael Karin +1 more
TL;DR: In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the inflammatory state.
Journal ArticleDOI
An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications.
Raed A. Dweik,Peter B. Boggs,Serpil C. Erzurum,Charles G. Irvin,Margaret W. Leigh,Jon O. Lundberg,Anna-Carin Olin,Alan L. Plummer,D. Robin Taylor +8 more
TL;DR: Recommendations to develop evidence-based guidelines for the interpretation of Fe(NO) measurements that incorporate evidence that has accumulated over the past decade are provided.
Journal ArticleDOI
Asthma. From bronchoconstriction to airways inflammation and remodeling.
TL;DR: This work has shown that chronic inflammation in the different forms of Asthma can affect both the severity and duration of the symptoms of the disease and the treatment options for these conditions vary greatly.
Journal ArticleDOI
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
Helen K. Reddel,D. Robin Taylor,Eric D. Bateman,Louis-Philippe Boulet,Homer A. Boushey,William W. Busse,Thomas B. Casale,Pascal Chanez,Paul L. Enright,Peter G. Gibson,Johan C. de Jongste,Huib A. M. Kerstjens,Stephen C. Lazarus,Mark L Levy,Paul M. O'Byrne,Martyn R Partridge,Ian D. Pavord,Malcolm R. Sears,Peter J. Sterk,Stuart W. Stoloff,Sean D. Sullivan,Stanley J. Szefler,Mike Thomas,Sally E. Wenzel +23 more
TL;DR: New definitions for asthma control, severity, and exacerbations are developed, based on current treatment principles and clinical and research relevance, to provide a basis for a multicomponent assessment of asthma by clinicians, researchers, and other relevant groups in the design, conduct, and evaluation of clinical trials, and in clinical practice.
References
More filters
Journal ArticleDOI
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells
TL;DR: The inhibition of the induction of an NO synthase by glucocorticoids is a receptor-mediated event involving the inhibition ofThe synthesis of mRNA for de novo synthesis of this enzyme may contribute to the pathophysiology of immunologically based conditions.
Journal ArticleDOI
Endogenous Nitric Oxide Is Present in the Exhaled Air of Rabbits, Guinea Pigs and Humans
TL;DR: The experiments suggest that NO may play both vascular regulatory and host defence roles in pulmonary physiology and pathophysiology.
Journal ArticleDOI
Measurement of nitric oxide in biological models.
TL;DR: The pharmacology and toxicology of NO is described, and the major techniques for measuring NO in biological models are reviewed and several new amperometric microelectrode assays offer the potential to measure smaller amounts of NO, permitting NO measurement in intact issues and from single cells.
Journal ArticleDOI
Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans.
TL;DR: In human tracheal segments, it is demonstrated that this response is mediated entirely by nitric oxide, since an inhibitor of NO synthesis, L-NG-nitroarginine methyl ester (L-NAME) (10(-4) M) abolishes this neural response.
Journal ArticleDOI
Generation of nitric oxide by human neutrophils
TL;DR: It is demonstrated that human neutrophils are capable of generating nitric oxide through dissociation of nitrite anion production from the respiratory burst and lysosomal enzyme release.