Journal ArticleDOI
Increased Pyramidal Excitability and NMDA Conductance Can Explain Posttraumatic Epileptogenesis Without Disinhibition: A Model
Reads0
Chats0
TLDR
Increasing the excitability of pyramidal cells and the strength of NMDA conductances, in the face of either unaltered or increased inhibition, resulted in generation of epileptiform activity that had characteristics similar to those of the experimental data.Abstract:
Partially isolated cortical islands prepared in vivo become epileptogenic within weeks of the injury. In this model of chronic epileptogenesis, recordings from cortical slices cut through the injur...read more
Citations
More filters
Journal ArticleDOI
Neuron: A Tool for Neuroscientists
TL;DR: This article describes two tools that address the problem of how to achieve computational efficiency and accuracy in simulation environments for neurons.
Journal ArticleDOI
NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail.
Padraig Gleeson,Sharon M. Crook,Robert C. Cannon,Michael L. Hines,Guy Billings,Matteo Farinella,Thomas M. Morse,Andrew P. Davison,Subhasis Ray,Upinder S. Bhalla,Simon R Barnes,Yoana D Dimitrova,R. Angus Silver +12 more
TL;DR: The development of NeuroML as a common description language for biophysically detailed neuronal and network models enables interoperability across multiple simulation environments, thereby improving model transparency, accessibility and reuse in computational neuroscience.
Journal ArticleDOI
Interictal spikes in focal epileptogenesis
TL;DR: It is proposed that the strong after-inhibition produced by IS protects against the occurrence of ictal discharges by maintaining a low level of excitation in a general condition of hyperexcitability determined by the primary epileptogenic dysfunction.
Book
Neuronal Substrates of Sleep and Epilepsy
TL;DR: This paper presents a meta-anatomy of the thalamocortical systems developing from low-frequency sleep oscillations in mice and describes the mechanisms of seizures.
Journal ArticleDOI
Role of Mossy Fiber Sprouting and Mossy Cell Loss in Hyperexcitability: A Network Model of the Dentate Gyrus Incorporating Cell Types and Axonal Topography
TL;DR: A biophysically realistic and anatomically representative computational model of the dentate gyrus showed that even weak mossy fiber sprouting resulted in the spread of seizure-like activity to the adjacent model hippocampal laminae after focal stimulation of the perforant path.
References
More filters
Journal ArticleDOI
The NEURON simulation environment
TL;DR: This work presents the basic ideas that would help informed users make the most efficient use of NEURON, the powerful and flexible environment for implementing models of individual neurons and small networks of neurons.
Journal ArticleDOI
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.
TL;DR: Slices of sensorimotor and anterior cingulate cortex from guinea pigs were maintained in vitro and bathed in a normal physiological medium, observing three distinct neuronal classes of electrophysiological behavior; these were regular spiking, bursting, and fast spiking.
Journal ArticleDOI
Intrinsic firing patterns of diverse neocortical neurons.
TL;DR: The different firing properties of neurons in neocortex contribute significantly to its network behavior, particularly in response to current steps.
Journal ArticleDOI
A new cellular mechanism for coupling inputs arriving at different cortical layers.
TL;DR: The coincidence of a single back-propagating action potential with a subthreshold distal excitatory postsynaptic potential to evoke a burst of axonal action potentials represents a new mechanism by which the main cortical output neurons can associate inputs arriving at different cortical layers.
Journal ArticleDOI
A Population-Based Study of Seizures after Traumatic Brain Injuries
TL;DR: The increased risk of seizures after traumatic brain injury varies greatly according to the severity of the injury and the time since the injury.
Related Papers (5)
Epileptogenesis in chronically injured cortex: in vitro studies.
David A. Prince,Guo-Fang Tseng +1 more