Journal ArticleDOI
Indium-111-labeled girentuximab immunoSPECT as a diagnostic tool in clear cell renal cell carcinoma.
Constantijn H.J. Muselaers,Otto C. Boerman,Egbert Oosterwijk,Johannes F. Langenhuijsen,Wim J.G. Oyen,Peter F.A. Mulders +5 more
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TLDR
Immuno-single-photon emission computed tomography (immunoSPECT) imaging with the indium-111 ((111)In)-labeled anti-CAIX antibody girentuximab in patients presenting with either a primary renal tumor or a history of ccRCC and lesions suspect for metastases during follow-up is presented.About:
This article is published in European Urology.The article was published on 2013-06-01. It has received 69 citations till now. The article focuses on the topics: Girentuximab & Clear cell renal cell carcinoma.read more
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Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma: The ARISER Randomized Clinical Trial
Karim Chamie,Nicholas M. Donin,Pia Klöpfer,Paul Bevan,Barbara Fall,Olaf Wilhelm,Stephan Störkel,Jonathan W. Said,Michael Gambla,Robert E. Hawkins,Gustavo Jankilevich,Anil Kapoor,Evgeny Kopyltsov,Michael Staehler,Kimmo Taari,Alberto J. A. Wainstein,Allan J. Pantuck,Arie S. Belldegrun +17 more
TL;DR: Girentuximab had no clinical benefit as adjuvant treatment for patients with high-risk ccRCC, and the surprisingly long DFS and OS in these patients represent a challenge to adjUvantccRCC drug development.
Journal ArticleDOI
Tumor-targeted Dual-modality Imaging to Improve Intraoperative Visualization of Clear Cell Renal Cell Carcinoma: A First in Man Study.
Marlène C.H. Hekman,Mark Rijpkema,Constantijn H.J. Muselaers,Egbert Oosterwijk,C.A. Hulsbergen-van de Kaa,Otto C. Boerman,Wim J.G. Oyen,Johannes F. Langenhuijsen,Peter F.A. Mulders +8 more
TL;DR: This first in man study shows that tumor-targeted dual-modality imaging using 111In-DOTA-girentuximab-IRDye800CW is safe and can be used for intraoperative guidance of ccRCC resection.
Journal ArticleDOI
Diagnostic Imaging for Solid Renal Tumors: A Pictorial Review.
TL;DR: The ability to detect and differentiate renal cell carcinoma subtypes, angiomyolipoma and oncocytoma based on ultrasound imaging, computed tomography, multiparametric magnetic resonance, and nuclear imaging is discussed.
Journal ArticleDOI
Application of Monoclonal Antibody G250 Recognizing Carbonic Anhydrase IX in Renal Cell Carcinoma
TL;DR: cG250-Based radio immuno-therapy (RIT) holds promise for treatment of patients with small-volume disease, and adjuvant treatment with unmodified cG250 may be of value in selected cases, and whether cG 250-based RIT can be combined with tyrosine kinase inhibitors, which constitutes the current standard treatment for mRCC needs to be established.
Journal ArticleDOI
Intraoperative Imaging Techniques to Support Complete Tumor Resection in Partial Nephrectomy
Marlène C.H. Hekman,Mark Rijpkema,Johan F. Langenhuijsen,Otto C. Boerman,Egbert Oosterwijk,Peter F.A. Mulders +5 more
TL;DR: The value of various intraoperative imaging techniques that may help a urologist achieve complete tumor resection in nephron-sparing surgery for kidney tumors are discussed.
References
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Journal Article
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: Implications for prognosis and therapy
Matthew H. T. Bui,David Seligson,Ken Ryu Han,Allan J. Pantuck,Frederick J. Dorey,Yunda Huang,Steve Horvath,Bradley C. Leibovich,Shefali Chopra,Shu Yuan Liao,Eric J. Stanbridge,Michael I. Lerman,Aarno Palotie,Robert A. Figlin,Arie S. Belldegrun +14 more
TL;DR: Lower CAIX levels are independently associated with poor survival in advanced RCC, which reflects significant changes in tumor biology, which should be used to predict clinical outcome and identify high-risk patients in need for adjuvant immunotherapy and CAIX-targeted therapies.
Journal Article
Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix - Loop - helix DNA binding segment
Jaromir Pastorek,Silvia Pastorekova,Isabelle Callebaut,Jp. Mornon,V. Zelnik,R. Opavsky,Miriam Zatovicova,S. Liao,Daniel Portetelle,Ej. Stanbridge,Jan Zavada,A. Burny,R. Kettmann +12 more
TL;DR: The analysis of biological consequences of MN expression of NIH3T3 cells provides the evidence in favour of MN protein involvement in control of cell proliferation and transformation.
Journal ArticleDOI
Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
René Opavský,Silvia Pastorekova,V. Zelnik,Adriana Gibadulinova,Eric J. Stanbridge,Jan Zavada,Richard Kettmann,Jaromir Pastorek +7 more
TL;DR: This study isolates, sequenced, and characterized a human MN/CA9 gene, a novel member of the carbonic anhydrase (CA) family, which codes for widely distributed catalysts of the reversible conversion of carbon dioxide to carbonic acid, and examines its biological function.
Journal ArticleDOI
Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney.
E. Oosterwdk,D. J. Ruiter,Ph. J. Hoedemaeker,Ernest K. J. Pauwels,U. Jonas,I. Zwartendijk,Sven O. Warnaar +6 more
TL;DR: A monoclonal antibody designated G 250, subclass IgGI, that recognizes an antigen preferentially expressed on cell membranes of renalcell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium is described.
Journal ArticleDOI
Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (124I-cG250) and PET in patients with renal masses: a phase I trial
Chaitanya R. Divgi,Neeta Pandit-Taskar,Achim A. Jungbluth,Victor E. Reuter,Mithat Gonen,Shutian Ruan,Christine Pierre,Andrew Nagel,Daniel A. Pryma,John L. Humm,Steven M. Larson,Lloyd J. Old,Paul Russo +12 more
TL;DR: In this paper, a single intravenous infusion of 185 MBq/10 mg of 124 I-cG250 over 20 min was performed on 26 patients with renal masses who were scheduled to undergo surgical resection by laparotomy and all nine non-clear-cell renal masses were negative for the tracer.