Journal ArticleDOI
Indole Alkaloids with Potential Anticancer Activity
TLDR
This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship and mechanisms of action covering the articles published from 2015 to 2020.Abstract:
Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert anticancer activity via various antiproliferative mechanisms, and some of them, such as Vinblastine and Vincristinem, have already used in clinics or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship, and mechanisms of action covering the articles published from 2015 to 2020.read more
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1,2,3-Triazole-Containing Compounds as Anti-Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure-Activity Relationship.
TL;DR: In this article, the authors summarize the recent advances in 1,2,3-triazole-containing compounds with anti-lung cancer potential, and their structure-activity relationship (SAR) together with mechanisms of action is also discussed to pave the way for the further rational development of novel anti-Lung cancer candidates.
Journal ArticleDOI
Current status of carbazole hybrids as anticancer agents.
TL;DR: In this paper, a review of the recent progress in knowledge on anticancer properties, structure-activity relationships, and mechanisms of action of carbazole hybrids to provide a basis for development of relevant therapeutic agents is presented.
Journal ArticleDOI
Current status of carbazole hybrids as anticancer agents
TL;DR: In this article , a review of the recent progress in knowledge on anticancer properties, structure-activity relationships, and mechanisms of action of carbazole hybrids to provide a basis for development of relevant therapeutic agents is presented.
Journal ArticleDOI
Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review.
Saikat Mitra,Shajuthi Rahman Prova,Sifat Ara Sultana,Rajib Das,Firzan Nainu,Talha Bin Emran,Abu Montakim Tareq,Md. Sahab Uddin,Ali Alqahtani,Kuldeep Dhama,Jesus Simal-Gandara +10 more
TL;DR: In this article, the authors summarized the in-depth therapeutic potential of indole alkaloids against various respiratory disorders, including asthma, emphysema, tuberculosis, cancer, and pulmonary fibrosis.
Journal ArticleDOI
New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689.
Olesya I Zhuravleva,Olesya I Zhuravleva,Alexandr S. Antonov,Vo Thi Dieu Trang,M. V. Pivkin,Yuliya V. Khudyakova,Vladimir A. Denisenko,Roman S. Popov,Natalya Y. Kim,Ekaterina A. Yurchenko,Andrey V. Gerasimenko,Anatoly A. Udovenko,Gunhild von Amsberg,Sergey A. Dyshlovoy,Shamil Sh. Afiyatullov +14 more
TL;DR: In this paper, seven new deoxyisoaustamide derivatives (1,7) together with known compounds (8,10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689.
References
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Navriti Chadha,Om Silakari +1 more
TL;DR: An overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs is provided to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations.
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Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
Waseem Gul,Mark T. Hamann +1 more
TL;DR: Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism and other pharmacological activities.
Journal ArticleDOI
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives.
Archana Kumari,Rajesh K. Singh +1 more
TL;DR: This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring and emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogues accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years.