Journal ArticleDOI
Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin.
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This article is published in Biochemistry.The article was published on 1974-05-07. It has received 275 citations till now. The article focuses on the topics: Methemoglobin & Globin.read more
Citations
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Journal ArticleDOI
Kinetic and thermodynamic parameters of the iron spin-state transition in human aquomethemoglobin.
TL;DR: It is demonstrated that a scheme that includes a fast spin transition of the iron atoms, preceding formate binding, adequately accounts for formatebinding to aquomethemoglobin in the T and R quaternary states.
Journal ArticleDOI
Solution studies on heme proteins circular dichroism and optical rotation of Glycera dibranchiata hemoglobins
TL;DR: The removal of the heme moiety from the monomer hemoglobin did result in a major decrease in its helix content similar to the loss of heme from myoglobin.
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The structure of hemoglobin Creteil (beta 89 Ser replaced by Asn) is similar to that of abnormal human hemoglobins having sequence changes at Tyr 145 beta.
A Arnone,J Thillet,J Rosa +2 more
TL;DR: Direct comparison of the difference electron density map of deoxyhemoglobin Creteil with that of de oxygenhemoglobin Nancy suggests that these two abnormal hemoglobins may have the same mechanism of dysfunction despite the very different nature of their respective sequence changes.
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Spectral evidence for two forms of acid ferrihemoglobin.
TL;DR: A quantitative analysis of the spectral changes suggests that the effect of glycerol on ferrihemoglobin can in large part be ascribed to its effect on the activity of the solvent water.
Journal ArticleDOI
Transition of hemoglobin between two tertiary conformations : The transition constant differs significantly for the major and minor hemoglobins of the Japanese quail (Cortunix cortunix japonica)
TL;DR: It is demonstrated that 5,5'-dithiobis(2-nitrobenzoate) - DTNB - reacts with only CysF9[93]beta and CysB5[23]beta among the multiple sulfhydryl groups of the major and minor hemoglobins of the Japanese quail (Cortunix cortunix japonica).
References
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X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhaemoglobin.
TL;DR: DPG has a two-fold effect on human deoxyhaemoglobin: it both stabilizes and slightly distorts the S form, and may therefore affect the solubility.
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Stereochemistry of cooperative effects in hemoglobin.
M. F. Perutz,L. F. TenEyck +1 more
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Rates and Mechanisms of Substitution in Inorganic Complexes in Solution.
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Nature of Haem–Haem Interaction
TL;DR: Dr Perutz describes how spin changes that accompany reaction with ligands alter the oxygen affinity of the haems.
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The interaction of 2,3-diphosphoglycerate with various human hemoglobins
TL;DR: Results suggest that the N-terminal amino groups of the non-α-chains are involved in the binding of 2,3-DPG to hemoglobin.