Journal ArticleDOI
Influence of insulin and testosterone on adrenocortical steroidogenesis in vitro: preliminary studies.
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TLDR
It is clear that extra-adrenal factors such as insulin and T have some adrenal regulatory capacity, and insulin stimulated DHEAS and decreased DHEA production, suggesting that it increases adrenocortical sulfotransferase activity.About:
This article is published in Fertility and Sterility.The article was published on 2001-10-01. It has received 42 citations till now. The article focuses on the topics: Polycystic ovary & Dehydroepiandrosterone sulfate.read more
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Journal ArticleDOI
Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity
Kristen A Neville,Jan L Walker +1 more
TL;DR: Both prematurity and SGA were associated with precocious pubarche, as was overweight/obesity, irrespective of size or gestation at birth, and excess weight gain in childhood may predispose to precociouspubarche in susceptible individuals.
Journal ArticleDOI
DHEA, DHEAS and PCOS.
TL;DR: Women with PCOS and APA excess appear to have a generalized exaggeration in adrenal steroidogenesis in response to ACTH stimulation, although they do not have an overt hypothalamic-pituitary-adrenal axis dysfunction.
Journal ArticleDOI
The adrenal and polycystic ovary syndrome.
Bulent O. Yildiz,Ricardo Azziz +1 more
TL;DR: DHEAS levels and the response of AAs to ACTH are relatively constant over time and are closely correlated between PCOS patients and their siblings suggesting that this abnormality is an inherited trait in PCOS.
Journal ArticleDOI
Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial.
Beata Banaszewska,Joanna Wrotyńska-Barczyńska,Robert Z. Spaczynski,Leszek Pawelczyk,Antoni J. Duleba +4 more
TL;DR: Resveratrol significantly reduced ovarian and adrenal androgens and may be, at least in part, related to an improvement of insulin sensitivity and a decline of insulin level.
Journal ArticleDOI
C-peptide, IGF-I, sex-steroid hormones and adiposity: A cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC)
Irene D. Bezemer,Irene D. Bezemer,Sabina Rinaldi,Laure Dossus,Carla H. van Gils,Petra H.M. Peeters,Paulus A.H. van Noord,H. Bas Bueno-de-Mesquita,Søren Paaske Johnsen,Kim Overvad,Anja Olsen,Anne Tjønneland,Heiner Boeing,Petra H. Lahmann,Jakob Linseisen,Gabriele Nagel,Naomi E. Allen,Andrew W. Roddam,Sheila Bingham,Kay-Tee Khaw,Emmanuelle Kesse,Bertrand Tehard,Françoise Clavel-Chapelon,Antonio Agudo,Eva Ardanaz,J. R. Quirós,Pilar Amiano,Carmen Martinez-Garcia,M. J. Tormo,Valeria Pala,Salvatore Panico,Paolo Vineis,Domenico Palli,Rosario Tumino,Antonia Trichopoulou,Nikos Baibas,D. Zilis,Bertrand Hémon,Teresa Norat,Elio Riboli,Rudolf Kaaks +40 more
TL;DR: Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids, and IGF-I was positively associated with post menopausal estrogens and androgen concentrations in all women.
References
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Journal ArticleDOI
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.
TL;DR: Since PCOS usually has a menarchal age of onset, this makes it a particularly appropriate disorder in which to examine the ontogeny of defects in carbohydrate metabolism and for ascertaining large three-generation kindreds for positional cloning studies to identify NIDDM genes.
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Prevalence of the polycystic ovary syndrome in unselected Black and White women of the Southeastern United States : A prospective study
Eric S. Knochenhauer,Timothy J. Key,Melissa Kahsar-Miller,W. Waggoner,Larry R. Boots,Ricardo Azziz +5 more
TL;DR: In a consecutive population of unselected women the prevalence of hirsutism varied from 2-8% depending on the chosen cut-off F-G score, with no significant difference between White and Black women.
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Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood
TL;DR: A longitudinal analysis of weekly specimens from 4 normal men, aged 36-59 yr, revealed individual variability (mean coefficient of variation, 19%) and failed to demonstrate any monthly, seasonal, or annual rhythmicity.
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Regulation of the acute production of steroids in steroidogenic cells.
TL;DR: This chapter will focus on studies designed to elucidate the mechanisms involved in the acute regulation of steroid production in response to hormone stimulation.
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Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis
TL;DR: The splanchnic nerve in regulating adrenocortical neural function and the influence of adrenal innervation on adrenOCortical function are studied.