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Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface
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The influenza A virus M 2 protein is expressed abundantly at the cell surface, and in addition to the hemagglutinin (HA) and neuraminidase (NA), is a third virus-specific membrane protein this paper.About:
This article is published in Cell.The article was published on 1985-03-01. It has received 557 citations till now. The article focuses on the topics: Neuraminidase & Hemagglutinin (influenza).read more
Citations
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Influenza virus M2 protein has ion channel activity.
TL;DR: Analysis of the currents of altered M2 proteins suggests that the channel pore is formed by the transmembrane domain of the M2 protein, which is proposed to have a pivotal role in the biology of influenza virus infection.
Journal ArticleDOI
A universal influenza A vaccine based on the extracellular domain of the M2 protein.
TL;DR: The enhanced immunogenicity of the M2 extracellular domain exposed on HBc particles allows broad-spectrum, long-lasting protection against influenza A infections.
Journal ArticleDOI
The molecular basis of the specific anti-influenza action of amantadine.
TL;DR: The data reported here demonstrate that the basis of these actions is similar and resides in the virus‐coded M2 membrane protein, the product of a spliced transcript of RNA segment 7.
Journal ArticleDOI
Topogenic signals in integral membrane proteins.
TL;DR: A positive-inside rule seems to apply universally to all integral membrane proteins, with apolar regions targeting for membrane integration and charged residues providing the topological information.
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Influenza virus assembly and budding.
TL;DR: This review investigates the latest research on influenza virus budding in an attempt to provide a step-by-step analysis of the assembly and budding processes for influenza viruses.
References
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TL;DR: The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet is positioned on top of this stem.
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Influenza virus M2 protein has ion channel activity.
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