Inhibition of 125I-asialofetuin catabolism by leupeptin in the perfused rat liver and in vivo.
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This article is published in Journal of Biological Chemistry.The article was published on 1979-05-25 and is currently open access. It has received 96 citations till now. The article focuses on the topics: Leupeptin & Catabolism.read more
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The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes
TL;DR: Serial sectioning indicated that tubular structures in Golgi-lysosome regions were often interconnected to the larger vesicles, but that tubules in the peripheral cytoplasm were only occasionally connected to larger structures.
Journal ArticleDOI
Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.
TL;DR: This is the slowest metabolic event involved in the catabolism of asialofetuin by the liver both in the perfused organ and in vivo, and in situ electron microscopic autoradiography revealed that fusion between pinocytic vesicles and lysosomes did not occur below 20 degrees C, despite the continued endocytosis.
Journal ArticleDOI
Isolation and Characterization of Rat Liver Amphisomes: EVIDENCE FOR FUSION OF AUTOPHAGOSOMES WITH BOTH EARLY AND LATE ENDOSOMES
TL;DR: In this paper, a quantitative electron microscopic study confirmed that leupeptin induced a severalfold increase in the number of hepatocytic amphisomes (recognized by their gold particle contents; otherwise, their ultrastructure was quite similar to autophagosomes).
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Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.
W A Dunn,A L Hubbard +1 more
TL;DR: Results suggest that EGF receptors are internalized and that their rate of recycling to the surface from intracellular sites is governed by the rate of entry of ligand and/or receptor into lysosomes.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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The thiobarbituric acid assay of sialic acids.
TL;DR: This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids.
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Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
TL;DR: The results are shown to favour the ferryl ion structure, or an isomer of this structure, for the higher oxidation state, and theHigher oxidation state may provisionally be named ferrylmyoglobin.
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A modified ninhydrin colorimetric analysis for amino acids
TL;DR: The present method avoids the necessity for the preparation of solutions of reduced ninhydrin, which is an unstable reagent difficult to prepare and impracticable to store.