Inhibition of Nuclear Factor κB Activation by a Virus-encoded IκB-like Protein
Yolanda Revilla,Mario Callejo,Javier M. Rodríguez,Esther Culebras,Maria L. Nogal,María L. Salas,Eladio Viñuela,Manuel Fresno +7 more
TLDR
Results indicate that the African swine fever virus IκB gene homologue interferes with NF-κB activation, likely representing a new mechanism to evade the immune response during viral infection.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-02-27 and is currently open access. It has received 127 citations till now. The article focuses on the topics: African swine fever virus & Virus.read more
Citations
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Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures.
TL;DR: Applied aspects that arise from an increase in knowledge in this area are described, including vaccine design and manufacture, the development of novel antiviral drugs and the use of IFN-sensitive oncolytic viruses in the treatment of cancer.
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Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures.
TL;DR: The aim of this book is to provide a chronology of events leading up to and including the invention of the insulin pump and its use in the treatment of central nervous disease.
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Inhibiting NF-κB activation by small molecules as a therapeutic strategy
TL;DR: Only small molecules that suppress NF-κB activation are described, and the mechanism by which they block this pathway is described.
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The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation
TL;DR: IkappaBalpha regulates the transcription factor NF-kappaB through the formation of stable Ikappa-Balpha/NF-KappaB complexes as discussed by the authors, which allows large en bloc movement of the p65 subunit amino-terminal domain.
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Inhibitors of NF-kappaB signaling: 785 and counting.
TL;DR: Over 750 inhibitors of the NF-κB pathway have been identified, including a variety of natural and synthetic molecules, which include antioxidants, peptides, small RNA/DNA, microbial and viral proteins, small molecules, and engineered dominant-negative or constitutively active polypeptides.
References
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
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Function and activation of NF-kappa B in the immune system.
TL;DR: The inhibition of NF-kappa B activation by antioxidants and specific protease inhibitors may provide a pharmacological basis for interfering with these acute processes in suppressing toxic/septic shock, graft-vs-host reactions, acute inflammatory reactions, severe phase response, and radiation damage.
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NF-κB: Ten Years After
TL;DR: The manuscript and the Figures and Table are based on a manuscript originally written by Gordon C. Dickinson in 2012 and then edited by David I. Dickinson and revised by David A. Dickinson.
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Structure, regulation and function of NF-kappa B.
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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
TL;DR: Results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B, the transcription factor inhibited by I kappa B-alpha.