Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo.
P Cochard,Denise Paulin +1 more
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The appearance of neurofilaments (NFs) and vimentin (Vim) in the nervous system of the mouse embryo was documented using immunohistochemical techniques and correlates extremely well with neurofibrillar differentiation and with the expression of adrenergic neurotransmitter properties.Abstract:
The appearance of neurofilaments (NFs) and vimentin (Vim) in the nervous system of the mouse embryo was documented using immunohistochemical techniques. The three NF protein subunits appear early and simultaneously in central and peripheral neurons at 9 to 10 days of gestation. The onset of NF expression is concomitant with axon elongation and correlates extremely well with neurofibrillar differentiation and, in the case of autonomic ganglia, with the expression of adrenergic neurotransmitter properties. In the central and peripheral nervous system, NF expression is preceded by that of Vim, and both types of intermediate filaments coexist within the same cell for a short period of time.read more
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Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
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Isolation of a stem cell for neurons and glia from the mammalian neural crest
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Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons.
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Mice lacking vimentin develop and reproduce without an obvious phenotype
Emma Colucci-Guyon,Marie-Madeleine Portier,Irene Dunia,Denise Paulin,Sandrine Pournin,Charles Babinet +5 more
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References
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Intermediate filaments as mechanical integrators of cellular space
TL;DR: Five chemically distinct classes of intermediate filaments can be identified within higher eukaryotic cells and may function to integrate mechanically the various structures of the cytoplasmic space in a way that is tailored to the differentiated state of the cell.
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The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.
Paul N. Hoffman,Raymond J. Lasek +1 more
TL;DR: The demonstration on SDS gels that the slow component of axonal transport is composed of a small number of polypeptides which have identical molecular weights in neurons from different mammalian species suggests that these polypePTides comprise fundamental structures of vertebrate neurons.
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Immunocytochemical demonstration of vimentin in astrocytes and ependymal cells of developing and adult mouse nervous system.
TL;DR: The results show that vimentin and GFA protein coexist in one cell type not only in primary cultures in vitro but also in the intact tissue in situ.
Journal ArticleDOI
All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody
TL;DR: It is suggested that all vertebrate and invertebrate intermediate filament proteins share a common antigenic determinant and the possibility that all intermediate filaments contain a 66,000 molecular weight protein.
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