Journal ArticleDOI
Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse
Muireann Coen,Stefan U. Ruepp,John C. Lindon,Jeremy K. Nicholson,Francois Pognan,Eva M. Lenz,Ian D. Wilson +6 more
TLDR
Gene chip array (Affymetrix) and high resolution 1H NMR spectra together offer a complementary view into cellular responses to toxic processes, providing new insight into the toxic consequences, even for well-studied therapeutic agents such as acetaminophen.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2004-04-01. It has received 153 citations till now. The article focuses on the topics: Glycogen & Glycolysis.read more
Citations
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Journal ArticleDOI
Chemometrics in Metabonomics
TL;DR: An overview of how the underlying philosophy of chemometrics is integrated throughout metabonomic studies is provided, including the tools applied for linear modeling, for example, Statistical Experimental Design (SED), Principal Component Analysis (PCA), Partial least-squares (PLS), Orthogonal-PLS, and dynamic extensions thereof.
Journal ArticleDOI
Metabolomics: Current analytical platforms and methodologies
Warwick B. Dunn,David I. Ellis +1 more
TL;DR: In this review, a new array of analytical methodologies and technologies were introduced related to the analysis of microbial, plant and animal metabolomes (complete collections of all low molecular weight compounds in a cell) and applications are discussed.
Journal ArticleDOI
Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.
Tomoyoshi Soga,Richard Baran,Makoto Suematsu,Yuki Ueno,Satsuki Ikeda,Tadayuki Sakurakawa,Yuji Kakazu,Takamasa Ishikawa,Martin Robert,Takaaki Nishioka,Masaru Tomita +10 more
TL;DR: A metabolome differential display method based on capillary electrophoresis time-of-flight mass spectrometry to profile liver metabolites following acetaminophen-induced hepatotoxicity finds that serum ophthalmate is a sensitive indicator of hepatic GSH depletion, and may be a new biomarker for oxidative stress.
Journal ArticleDOI
Metabolomics: A Global Biochemical Approach to Drug Response and Disease
TL;DR: This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures and highlights potential metabolomic applications to pharmacology and clinical pharmacology.
Journal ArticleDOI
Metabonomics in Toxicology: A Review
TL;DR: The jargon, logistics, and applications of the technology are covered in some detail with emphasis on recent work in the field and particular emphasis on toxicologic applications in preclinical drug development.
References
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PatentDOI
Expression monitoring by hybridization to high density oligonucleotide arrays
TL;DR: In this article, the authors proposed a method for monitoring the expression levels of a multiplicity of genes by hybridizing a nucleic acid sample to a high density array of oligonucleotide probes and quantifying the hybridized nucleic acids in the array.
Journal ArticleDOI
'metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological nmr spectroscopic data
TL;DR: Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data by using NMR data from Xenobiotica.
Journal ArticleDOI
High density synthetic oligonucleotide arrays
TL;DR: An approach in which sequence information is used directly to design high–density, two–dimensional arrays of synthetic oligonucleotides is developed, which have been designed and used for quantitative and highly parallel measurements of gene expression, to discover polymorphic loci and to detect the presence of thousands of alternative alleles.
Journal ArticleDOI
Metabonomics: a platform for studying drug toxicity and gene function
TL;DR: Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.
Journal ArticleDOI
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
TL;DR: The relationship between the metabolic disposition of acetaminophen and the susceptibility of hamsters, mice and rats toacetaminophen-induced liver necrosis has been examined.
Related Papers (5)
'metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological nmr spectroscopic data
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
John C. Lindon,Jeremy K. Nicholson,Elaine Holmes,Henrik Antti,Mary E. Bollard,Hector C. Keun,Olaf Beckonert,Timothy M. D. Ebbels,Michael D. Reily,Donald G. Robertson,Gregory J. Stevens,Peter Luke,Alan P. Breau,Glenn H. Cantor,Roy H. Bible,Urs Niederhauser,Hans Senn,Goetz Schlotterbeck,Ulla G. Sidelmann,Steen Møller Laursen,Adrienne A. Tymiak,Bruce D. Car,Lois D. Lehman-McKeeman,Jean-Marie Colet,Ali Loukaci,Craig E. Thomas +25 more