Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Giuliana Donadio,Francesca Mensitieri,Valentina Santoro,Valentina Parisi,Maria Laura Bellone,Nunziatina De Tommasi,Viviana Izzo,Fabrizio Dal Piaz +7 more
TLDR
In this article, the authors present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins, which demonstrate the great potential of these compounds in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.Abstract:
Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.read more
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Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation
Nur Farisya Shamsudin,Qamar Uddin Ahmed,Syed Aamir Mahmood,Syed Adnan Ali Shah,Alfi Khatib,Sayeed Mukhtar,Meshari A. Alsharif,Humaira Parveen,Zainul Amiruddin Zakaria +8 more
TL;DR: The latest information on the antibacterial activity of flavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products.
Journal ArticleDOI
Flavonoids a Bioactive Compound from Medicinal Plants and Its Therapeutic Applications
Arpita Roy,Ariba Khan,Irfan Ahmad,Saad Alghamdi,Bodour S Rajab,Ahmad O. Babalghith,Mohammad Y. Alshahrani,Saiful Islam,Md. Rabiul Islam +8 more
TL;DR: This review has highlighted the various types of flavonoids, their biosynthesis, properties, and different strategies to enhance the production of Flavonoids.
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Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations.
TL;DR: In this paper , a review summarizes the food associations of flavonoids, and discusses the mechanisms responsible for imparting them their nutraceutic properties, detailing the nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway, inhibition of inflammatory signaling pathways such as toll-like receptor (TLR), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), cyclooxygenase 2 (COX-2) and lipoxygenases-2 (LOX)-2) mediators.
Journal ArticleDOI
Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies.
TL;DR: Phenolic compounds are a large, heterogeneous group of secondary metabolites found in various plants and herbal substances and their utilization in cutaneous formulations sets challenges to drug development.
Journal ArticleDOI
Bioactivity and Therapeutic Potential of Kaempferol and Quercetin: New Insights for Plant and Human Health
TL;DR: This review summarizes the emerging potential of kaempferol and quercetin in terms of antimicrobial activity, bioavailability and bioactivity in the human body as well as in the regulation of plant defence in response to stresses and as a signalling molecule in Terms of hormonal modulation under stress conditions.
References
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Plant Products as Antimicrobial Agents
TL;DR: The current status of botanical screening efforts, as well as in vivo studies of their effectiveness and toxicity, are summarized and the structure and antimicrobial properties of phytochemicals are addressed.
Journal ArticleDOI
The Role of Root Exudates in Rhizosphere Interactions with Plants and Other Organisms
TL;DR: Recent advances in elucidating the role of root exudates in interactions between plant roots and other plants, microbes, and nematodes present in the rhizosphere are described.
Journal ArticleDOI
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Raimunda do Socorro da Silva Azevedo,Jorge Rodrigues de Sousa,Marialva Tereza Ferreira de Araújo,Arnaldo Jorge Martins Filho,Bianca Nascimento de Alcantara,Fernanda Montenegro de Carvalho Araújo,Maria G. L. Queiroz,Ana Cecília Ribeiro Cruz,Beatriz H. Baldez Vasconcelos,Jannifer Oliveira Chiang,Lívia Carício Martins,Livia Medeiros Neves Casseb,Eliana Vieira Pinto da Silva,Valéria Lima Carvalho,Barbara Cristina Baldez Vasconcelos,Sueli Rodrigues,Consuelo Silva de Oliveira,Juarez Antônio Simões Quaresma,Pedro Fernando da Costa Vasconcelos +18 more
TL;DR: The in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases were investigated and changes found were mainly calcification, necrosis, neuronophagy, gliosis, microglial nodules, and inflammatory infiltration of mononuclear cells.
Journal ArticleDOI
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Evelina Tacconelli,Elena Carrara,Alessia Savoldi,Stéphan Juergen Harbarth,Marc Mendelson,Dominique L Monnet,Céline Pulcini,Gunnar Kahlmeter,Jan Kluytmans,Yehuda Carmeli,Marc Ouellette,Kevin Outterson,Jean B. Patel,Marco Cavaleri,Edward Cox,Christopher R. Houchens,M Lindsay Grayson,Paul Hansen,Nalini Singh,Ursula Theuretzbacher,Nicola Magrini,Aaron O. Aboderin,Seif Al-Abri,Nordiah Awang Jalil,Nur Benzonana,Sanjay Bhattacharya,Adrian Brink,Francesco Robert Burkert,Otto Cars,Giuseppe Cornaglia,Oliver J. Dyar,Alexander W. Friedrich,Ana Cristina Gales,Sumanth Gandra,Christian G. Giske,Debra A. Goff,Herman Goossens,Thomas Gottlieb,Manuel Guzman Blanco,Waleria Hryniewicz,Deepthi Kattula,Timothy Jinks,Souha S. Kanj,Lawrence Kerr,Marie-Paule Kieny,Yang Soo Kim,Roman S. Kozlov,Jaime Labarca,Ramanan Laxminarayan,Karin Leder,Leonard Leibovici,Gabriel Levy-Hara,Jasper Littman,Surbhi Malhotra-Kumar,Vikas Manchanda,Lorenzo Moja,Babacar Ndoye,Angelo Pan,David L. Paterson,Mical Paul,Haibo Qiu,Pilar Ramon-Pardo,Jesús Rodríguez-Baño,Maurizio Sanguinetti,Sharmila Sengupta,Mike Sharland,Massinissa Si-Mehand,Lynn L. Silver,Wonkeung Song,Martin Steinbakk,Jens Thomsen,Guy E. Thwaites,Jos W. M. van der Meer,Nguyen Van Kinh,Silvio Vega,Maria Virginia Villegas,Agnes Wechsler-Fördös,Heiman F. L. Wertheim,Evelyn Wesangula,Neil Woodford,Fidan O Yilmaz,Anna Zorzet +81 more
TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.
Journal ArticleDOI
Chemistry and Biological Activities of Flavonoids: An Overview
Shashank Kumar,Abhay K. Pandey +1 more
TL;DR: The structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production are highlighted.