Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Dennis M. Willerford,Jianzhu Chen,Judith A. Ferry,Laurie Davidson,Averil Ma,Averil Ma,Frederick W. Alt,Frederick W. Alt +7 more
Reads0
Chats0
TLDR
Interleukin-2 receptor alpha chain expression occurs at specific stages of early T and B lymphocyte development and is induced upon activation of mature lymphocytes, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation.About:
This article is published in Immunity.The article was published on 1995-10-01 and is currently open access. It has received 1091 citations till now. The article focuses on the topics: B cell & Lymphocyte.read more
Citations
More filters
Journal ArticleDOI
Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses
TL;DR: How naturally arising CD25+CD4+ regulatory T cells contribute to the maintenance of immunologic self-tolerance and negative control of various immune responses, and how they can be exploited to prevent and treat autoimmune disease, allergy, cancer, and chronic infection, or establish donor-specific transplantation tolerance are discussed.
Journal ArticleDOI
Lymphocyte homing and homeostasis.
TL;DR: A review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed.
Journal ArticleDOI
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
TL;DR: Data support the concept that the CD4+CD25+ T cells in normal mice may represent a distinct lineage of “professional” suppressor cells.
Journal ArticleDOI
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.
TL;DR: Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance, and are a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
Journal ArticleDOI
Points of control in inflammation
TL;DR: The non-inflammatory state does not arise passively from an absence of inflammatory stimuli; rather, maintenance of health requires the positive actions of specific gene products to suppress reactions to potentially inflammatory stimuli that do not warrant a full response.
References
More filters
Book
Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
Interleukin-2: inception, impact, and implications.
TL;DR: Because T cell clonal proliferation after antigen challenge is obligatory for immune responsiveness and immune memory, the IL-2-T cell system has opened the way to a molecular understanding of phenomena that are fundamental to biology, immunology, and medicine.
Journal ArticleDOI
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.
TL;DR: The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus.