Journal ArticleDOI
Interleukin-6: An Overview
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This article is published in Annual Review of Immunology.The article was published on 1990-01-01. It has received 1873 citations till now. The article focuses on the topics: Interleukin 6.read more
Citations
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Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
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IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
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C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction A Potential Role for Cytokines Originating From Adipose Tissue?
TL;DR: The data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein, and that infection with H pylori, C pneumoniae, and cytomegalovirus is not.
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Associations of Depression With C-Reactive Protein, IL-1, and IL-6 : A Meta-Analysis
TL;DR: Continuity in clinic- and community-based samples suggests there is a dose-response relationship between depression and these inflammatory markers, lending strength to the contention that the cardiac risk conferred by depression is not exclusive to patient populations.
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Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
TL;DR: A role for cytokine-mediated inflammation in the early stages of atherogenesis is supported in apparently healthy men, and elevated levels of IL-6 are associated with increased risk of future MI.
References
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Journal ArticleDOI
The biology of interleukin-6.
TL;DR: Human IL-6 (BSF2) was originally identified as a factor in the culture supernatants of mitogen or antigen-stimulated peripheral mononuclear cells, which induced immunoglobulin production in Epstein Barr virus transformed B-cell lines or in Staphylococcus aureus Cowan 1 stimulated normal B cells.
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Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
Michio Kawano,Toshio Hirano,Tadashi Matsuda,Tetsuya Taga,Y Horii,Koji Iwato,Hideki Asaoku,Bo Tang,Osamu Tanabe,Hideo Tanaka,Atsushi Kuramoto,Tadamitsu Kishimoto +11 more
TL;DR: It is reported that myeloma cells freshly isolated from patients produce BSF-2 and express its receptors, direct evidence that an autocrine loop is operating in oncogenesis of human myelomas.
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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Tetsuya Taga,Masahiko Hibi,Y. Hirata,Katsuhiko Yamasaki,Kiyoshi Yasukawa,Tadashi Matsuda,Toshio Hirano,Tadamitsu Kishimoto +7 more
TL;DR: It is reported that an 80 kd single polypeptide chain (IL-6-R) is involved in IL-6 binding and that IL- 6 triggers the association of this receptor with a non-ligand-binding membrane glycoprotein, gp130, extracellularly and can provide the IL-7 signal.
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The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.
TL;DR: Data indicate that a complex pattern of cytokines exists in serum from patients with meningococcal septic shock, and that the release of IL-6 and IL-1, in addition to TNF-alpha, is associated with fatal outcome.
Journal ArticleDOI
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.
Marshall Plaut,Jacalyn H. Pierce,Cynthia J. Watson,J. Hanley-Hyde,Richard P. Nordan,William E. Paul +5 more
TL;DR: It is shown that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells).