Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction
Christian Valina,Kai Pinkernell,Yao-Hua Song,Xiaowen Bai,Sanga Sadat,Richard J. Campeau,Thierry H. Le Jemtel,Eckhard Alt,Eckhard Alt +8 more
TLDR
This is the first study to show that not only bone marrow-derived cells but also ADSCs engrafted in the infarct region 4 weeks after intracoronary cell transplantation and improved cardiac function and perfusion via angiogenesis.Abstract:
Aims This study was designed to assess whether intracoronary application of adipose tissue-derived stem cells (ADSCs) compared with bone marrow-derived stem cells (BMSCs) and control could improve cardiac function after 30 days in a porcine acute myocardial infarction/reperfusion model.
Methods and results An acute transmural porcine myocardial infarction was induced by inflating an angioplasty balloon for 180 min in the mid-left anterior descending artery. Two million cultured autologous stem cells were intracoronary injected through the central lumen of the inflated balloon catheter. Analysis of scintigraphic data obtained after 28 ± 3 days showed that both absolute and relative perfusion defect decreased significantly after intracoronary administration of ADSCs or BMSCs (relative 30 or 31%, respectively), compared with carrier administration alone (12%, P = 0.048). Left ventricular ejection fraction after 4 weeks increased significantly more after ADSC and BMSC administration than after carrier administration: 11.39 ± 4.62 and 9.59 ± 7.95%, respectively vs. 1.95 ± 4.7%, P = 0.02). The relative thickness of the ventricular wall in the infarction area after cell administration was significantly greater than that after carrier administration. The vascular density of the border zone also improved. The grafted cells co-localized with von Willebrand factor and alpha-smooth muscle actin and incorporated into newly formed vessels.
Conclusion This is the first study to show that not only bone marrow-derived cells but also ADSCs engrafted in the infarct region 4 weeks after intracoronary cell transplantation and improved cardiac function and perfusion via angiogenesis.read more
Citations
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Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells
TL;DR: Despite the minor differences between these MSC populations, ASCs seem to be as effective as BM-MSCs in clinical application, and, in some cases, may be better suited than BM- MSCs.
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Cell Therapy for Heart Failure: A Comprehensive Overview of Experimental and Clinical Studies, Current Challenges, and Future Directions
TL;DR: A critically review of the large body of work performed with respect to the use of stem/progenitor cells in HF, both at the experimental and clinical levels, and to discuss current controversies, unresolved issues, challenges, and future directions.
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Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
TL;DR: The evidence supporting the hypothesis that transplanted MSCs secrete factors to reduce tissue injury and/or enhance tissue repair is reviewed including the recent identification of exosome as a therapeutic agent in MSC secretion.
Journal ArticleDOI
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells.
Tao-Sheng Li,Ke Cheng,Konstantinos Malliaras,Rachel Ruckdeschel Smith,Yiqiang Zhang,Baiming Sun,Noriko Matsushita,Agnieszka Blusztajn,John Terrovitis,Hideo Kusuoka,Linda Marbán,Eduardo Marbán +11 more
TL;DR: CDCs exhibited a balanced profile of paracrine factor production and, among various comparator cell types/subpopulations, provided the greatest functional benefit in experimental myocardial infarction.
Journal ArticleDOI
The potential of adipose stem cells in regenerative medicine.
TL;DR: The safety, reproducibility and quality of the stem cells must thoroughly be examined prior to extensive use in clinical applications, as cell therapies are becoming more frequent and the need for control in the processing laboratory grows consequently involving a greater risk of complications and possibly adverse events for the recipient.
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Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
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Alfred Kocher,Michael D. Schuster,Matthias Szabolcs,Shin Takuma,Daniel Burkhoff,Jennifer Wang,Shunichi Homma,Niloo M. Edwards,Silviu Itescu +8 more
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