Journal ArticleDOI
Intracytoplasmic sperm injection for male infertility and consequences for offspring
Sandro C. Esteves,Sandro C. Esteves,Matheus Roque,Giuliano Bedoschi,Thor Haahr,Peter Humaidan +5 more
TLDR
Existing evidence does not support ICSI in preference over in vitro fertilization (IVF) in the general non-male factor ART population; however, in couples with unexplained infertility, I CSI is associated with lower fertilization failure rates than IVF.Abstract:
Intracytoplasmic sperm injection (ICSI) has become the most commonly used method of fertilization in assisted reproductive technology. The primary reasons for its popularity stem from its effectiveness, the standardization of the procedure, which means that it can easily be incorporated into the routine practice of fertility centres worldwide, and the fact that it can be used to treat virtually all forms of infertility. ICSI is the clear method of choice for overcoming untreatable severe male factor infertility, but its (over)use in other male and non-male factor infertility scenarios is not evidence-based. Despite all efforts to increase ICSI efficacy and safety through the application of advanced sperm retrieval and cryopreservation techniques, as well as methods for selecting sperm with better chromatin integrity, the overall pregnancy rates from infertile men remain suboptimal. Treating the underlying male infertility factor before ICSI seems to be a promising way to improve ICSI outcomes, but data remain limited. Information regarding the health of ICSI offspring has accumulated over the past 25 years, and there are reasons for concern as risks of congenital malformations, epigenetic disorders, chromosomal abnormalities, subfertility, cancer, delayed psychological and neurological development, and impaired cardiometabolic profile have been observed to be greater in infants born as a result of ICSI than in naturally conceived children. However, as subfertility probably influences the risk estimates, it remains to be determined to what extent the observed adverse outcomes are related to parental factors or associated with ICSI.read more
Citations
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Autism and Mental Retardation Among Offspring Born After in Vitro Fertilization
TL;DR: In this paper, the authors examined the association between use of any IVF and different IVF procedures and the risk of autistic disorder and mental retardation in the offspring and found that IVF treatment overall was not associated with autistic disorder but was associated with a small but statistically significantly increased risk of mental disorder.
Journal ArticleDOI
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.
Yonggang Lu,Seiya Oura,Takafumi Matsumura,Asami Oji,Nobuyuki Sakurai,Yoshitaka Fujihara,Keisuke Shimada,Haruhiko Miyata,Tomohiro Tobita,Taichi Noda,Julio M Castaneda,Daiji Kiyozumi,Qian Zhang,Qian Zhang,Tamara Larasati,Samantha A. M. Young,Samantha A. M. Young,Mayo Kodani,Caitlin A Huddleston,Matthew J. Robertson,Cristian Coarfa,Ayako Isotani,R. John Aitken,Masaru Okabe,Martin M. Matzuk,Thomas X. Garcia,Thomas X. Garcia,Masahito Ikawa +27 more
TL;DR: Thirty testis-enriched genes are dispensable for male fertility based on phenotypic analyses of knockout mice produced by the CRISPR/Cas9 system, suggesting these genes are individually dispensability for male reproduction.
Journal ArticleDOI
A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection: The ART Calculator.
TL;DR: A novel calculator to predict the POSEIDON marker may assist in clinical counseling and individualized treatment planning regarding the number of oocytes required for at least one euploid blastocyst in IVF/ICSI procedures.
Journal ArticleDOI
An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men.
TL;DR: Testing for sperm DNA fragmentation is associated with potentially treatable conditions, including varicocele, male accessory gland infections, inadequate lifestyle, and gonadotoxin exposure, thus prompting their treatment as a means of improving sperm DNA quality and the reproductive outcomes.
Cancer in children and young adults born after assisted reproductive technology: a Nordic cohort study from the Committee of Nordic ART and Safety (CoNARTaS)
Karin Jerhamre Sundh,Anna-Karina Aaris Henningsen,Karin Källén,Christina Bergh,Liv Bente Romundstad,Mika Gissler,Anja Pinborg,Rolv Skjærven,Aila Tiitinen,Ditte Vassard,Birgitta Lannering,Ulla-Britt Wennerholm +11 more
TL;DR: The main findings are reassuring for couples undergoing ART, children born after ART and clinicians working with ART, and the main limitation is the fact that it is not possible to adjust for all potential confounders.
References
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Journal ArticleDOI
Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte
TL;DR: Intracytoplasmic sperm injection is used to treat couples with infertility because of severely impaired sperm characteristics, and in whom IVF and SUZI had failed.
Journal ArticleDOI
ESHRE consensus on the definition of ‘poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria
Anna Pia Ferraretti,A. La Marca,Bart C.J.M. Fauser,Basil C. Tarlatzis,Geeta Nargund,Luca Gianaroli +5 more
TL;DR: The definition presented here represents the first realistic attempt by the scientific community to standardize the definition of poor ovarian response (POR) in a simple and reproducible manner and is uniformly adapted as the 'minimal' criteria needed to select patients for future clinical trials.
Journal ArticleDOI
Sperm morphologic features as a prognostic factor in in vitro fertilization.
Thinus F. Kruger,Roelof Menkveld,F. S. H. Stander,Carl Lombard,Jacobus P. Van der Merwe,Johannes A. van Zyl,Karen Smith +6 more
TL;DR: In this article, the authors conducted a prospective study in women with bilateral tubal damage to determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization (IVF) program.
Journal ArticleDOI
Predictive value of abnormal sperm morphology in in vitro fertilization
Thinus F. Kruger,Anibal A. Acosta,Anibal A. Acosta,K.F. Simmons,K.F. Simmons,R.J. Swanson,R.J. Swanson,J.F. Matta,J.F. Matta,Sergio Oehninger,Sergio Oehninger +10 more
TL;DR: By evaluating sperm morphology with the proposed strict criteria, its predictive value in in vitro fertilization is enhanced.
Journal ArticleDOI
The International Glossary on Infertility and Fertility Care, 2017
Fernando Zegers-Hochschild,G. David Adamson,Silke Dyer,Catherine Racowsky,Jacques de Mouzon,Rebecca Z. Sokol,Laura Rienzi,Arne Sunde,Lone Schmidt,Ian D. Cooke,Joe Leigh Simpson,Sheryl van der Poel +11 more
TL;DR: A consensus-based and evidence-driven set of 283 terminologies used in infertility and fertility care was generated to harmonize communication among health professionals and scientists as well as the lay public, patients and policy makers.