Journal ArticleDOI
Intrinsic and extrinsic regulation of the differentiation of skin, corneal and esophageal epithelial cells.
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TLDR
The finding that the morphological and biochemical differentiation of a given epithelium can be reversibly modulated by the external environment demonstrates that extrinsic factors may, under certain conditions, also play a role in regulating epithelial differentiation.About:
This article is published in Cell.The article was published on 1980-11-01. It has received 284 citations till now. The article focuses on the topics: Stratified squamous epithelium & Epithelium.read more
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The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
TL;DR: During cell transformation and tumor devel- opment this cell type specificity of intermediate filaments is largely conserved’ and classification of tumors by their specific type of intermediate Filaments has re- cently become very valuable in clinical histodiagnosis.
Journal ArticleDOI
Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.
TL;DR: Keratin expression data suggest that the acidic 55K and basic 64K keratins represent markers for an advanced stage of corneal epithelial differentiation.
Journal ArticleDOI
Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells.
TL;DR: Using 3H-thymidine labeling, a subpopulation of corneal epithelial basal cells are identified in the peripheral cornea in a region called limbus that are normally slow cycling, but can be stimulated to proliferate in response to wounding and to a tumor promotor, TPA.
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Keratin expression in human tissues and neoplasms.
Peiguo G. Chu,Lawrence M. Weiss +1 more
TL;DR: In this article, the molecular and cell biology of Keratin filaments are reviewed and the expression patterns of these filaments in various human epithelial neoplasms are analyzed, including simple epithelia generally express the simple epithelial keratins 7, 18, 19, and 20, while complex epithelias express complex epithelial Keratins 5/6, 10, 14, and 15.
Journal ArticleDOI
Regulation of terminal differentiation of cultured human keratinocytes by vitamin A
TL;DR: The fetal calf serum supplement of cell-culture medium contains enough of the vitamin to affect the differentiation of cultured keratinocytes derived from epidermis and from other stratified squamous epithelia.
References
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Journal ArticleDOI
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.
James G. Rheinwatd,Howard Green +1 more
TL;DR: Human diploid epidermis epidermal cells have been successfully grown in serial culture and it is possible to isolate keratinocyte clones free of viable fibroblasts, and human diploids keratinocytes appear to have a finite culture lifetime.
Journal ArticleDOI
Changes in keratin gene expression during terminal differentiation of the keratinocyte
Elaine Fuchs,Howard Green +1 more
TL;DR: Stratified squamous epithelia of internal organs do not form a typical stratum corneum and do not make the large keratins characteristic of epidermis, implying that they have embarked on an alternate route of terminal keratin synthesis.
Journal ArticleDOI
Different intermediate-sized filaments distinguished by immunofluorescence microscopy
TL;DR: Observations show that intermediate filaments with similar ultrastructure and solubility characteristics can be distinguished immunologically.
Journal ArticleDOI
Differentiation of the epidermal keratinocyte in cell culture: Formation of the cornified envelope
Tung-Tien Sun,Howard Green +1 more
TL;DR: Strain XB, an established keratinocyte line of mouse teratomal origin, also forms cornified envelopes, but the kinetics of the process are different, indicating that the program of terminal differentiation is not initiated at corresponding times in the two cell types.
Journal ArticleDOI
Keratin cytoskeletons in epithelial cells of internal organs.
TL;DR: The results show that keratins constitute a cytoskeleton in epithelial cells of diverse morphology and embryological origin and the stability of keratin filaments probably confers the structural strength necessary for cells covering a free surface.
Related Papers (5)
Changes in keratin gene expression during terminal differentiation of the keratinocyte
Elaine Fuchs,Howard Green +1 more
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.
James G. Rheinwatd,Howard Green +1 more