Investigation of medicinal plants from Madagascar against DPP-IV linked to type 2 diabetes
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TLDR
In this paper, high-resolution DPP-IV inhibition profiling was employed for identification of active peaks, and Antidesma madagascariense was identified as DPPIV inhibitor, with an IC50 value of 3.9 ± 0.5μM.About:
This article is published in South African Journal of Botany.The article was published on 2018-03-01 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Amentoflavone & Medicinal plants.read more
Citations
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The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites.
Wilson R. Tavares,Ana M. L. Seca +1 more
TL;DR: The Juniperus species value as a source of secondary metabolites with relevant pharmaceutical potential is demonstrated, withAntitumor activity is by far the most studied, being followed by antibacterial and antiviral activities.
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Facile Fabrication of an Amentoflavone-Loaded Micelle System for Oral Delivery To Improve Bioavailability and Hypoglycemic Effects in KKAy Mice.
Jun-Xia Zhang,Ji-Chun Zhou,Ting-Ting Zhang,Zhenxi Niu,Zhenxi Niu,Juan Wang,Jiao-Mei Guo,Zhen-Guo Li,Zhenzhong Zhang +8 more
TL;DR: The oral micelles of P(NVP-MGAM)/AF may become one of the most potent drugs in the treatment of diabetes mellitus, which opens up a new way for the prevention and treatment of Diabetes mellitus.
Iconography : DPP-4 inhibitors in the management of type 2 diabetes: A critical review of head-to-head trials
TL;DR: The role of DPP-4 inhibitors in the therapeutic armamentarium of type 2 diabetes is rapidly evolving as their potential strengths and weaknesses become better defined mainly through controlled clinical trials.
Journal ArticleDOI
Activity-guided isolation of α-amylase, α-glucosidase, and pancreatic lipase inhibitory compounds from Rhus coriaria L.
TL;DR: The results of high-performance liquid chromatography analysis showed that penta-O-galloyl-β-D-glycopyranose was one of the main compounds in both fruit and leaf extracts, and it may be considered that R. coriaria fruit and Leaf extracts can be standardized on this substance and used in the development of both medicinal products and functional food for diabetes.
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In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes
Patrick Nwabueze Okechukwu,Mridula Sharma,Wen Hui Tan,Hor Kuan Chan,Kavita Chirara,Anand Gaurav,Mayasah Al-Nema +6 more
TL;DR: The aim of the experiment is to evaluate the in vitro antidiabetic activity and in-silico studies of the binding energies of Palmatine, acarbose, and Sitagliptin with the three enzymes of alpha-amylase, alpha-glucosidase, and dipeptidyl peptidase-IV (DPP-IV).
References
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Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds
Cicero Lee-Tian Chang,Yenshou Lin,Arlene P. Bartolome,Arlene P. Bartolome,Yi-Ching Chen,Shao Chih Chiu,Wen-Chin Yang +6 more
TL;DR: Blood glucose-lowering medicinal herbs that have the ability to modulate one or more of the pathways that regulate insulin resistance, β-cell function, GLP-1 homeostasis, and glucose (re)absorption are selected and discussed.
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Recent discovery of plant-derived anti-diabetic natural products
Hsin Yi Hung,Keduo Qian,Susan L. Morris-Natschke,Chau Shin Hsu,Kuo Hsiung Lee,Kuo Hsiung Lee +5 more
TL;DR: In this review, recent discoveries of anti-diabetic compounds have been summarized according to their chemical structures and mechanisms of action.
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Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes.
TL;DR: DPP‑4 inhibitors are a new class of antidiabetogenic drugs that provide comparable efficacy to current treatments and are effective as monotherapy in patients inadequately controlled with diet and exercise and as add-on therapy in combination with metformin, thiazolidinediones, and insulin.
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DPP-4 inhibitors
TL;DR: DPP-4 inhibition is suggested to be a first-line treatment of type-2 diabetes, particularly in its early stages in combination with metformin, however, the durability and long-term safety of DPP- 4 inhibition remain to be established.
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DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.
TL;DR: DPP-4 inhibitors were less effective than GLP-1 receptor agonists for reducing HbA(1c) and body weight, but offer the advantage of being easier to use (oral instead of injected administration) and lower in cost.