Journal ArticleDOI
Irreversible binding of the chlorpromazine radical cation and of photoactivated chlorpromazine to biological macromolecules
N. J. De Mol,R.W. Busker +1 more
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TLDR
The irreversible binding of chlorpromazine radical cation (CPZ+.) and photoactivated chlor Promazine ( CPZ) to calf thymus DNA in vitro and bacterial macromolecules in intact bacterium cells was investigated and the consequences of covalent binding for the cytotoxicity and genotoxicity of CPZ+.About:
This article is published in Chemico-Biological Interactions.The article was published on 1984-11-01. It has received 39 citations till now.read more
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Serum Transaminase Elevations as Indicators of Hepatic Injury Following the Administration of Drugs
TL;DR: Some ancillary methods for early preclinical screening such as in vitro metabolism and toxicity assays, gene and protein expression analysis, and some strategies for enhancing the probability for the early detection of idiosyncratic hepatotoxic responses which are infrequent but significant factors in the safety assessment process are summarized.
Journal ArticleDOI
Evidence for cooperative binding of chlorpromazine with hemoglobin: equilibrium dialysis, fluorescence quenching and oxygen release study.
TL;DR: Binding of chlorpromazine with human hemoglobin has been studied by equilibrium dialysis and fluorescence quenching and results revealed that the binding was positively cooperative with overall affinity constant K = 3.8 x 10(3) M-1.
Journal ArticleDOI
Interaction of chlorpromazine with myoglobin and hemoglobin: A comparative study
TL;DR: Thermodynamic analysis revealed that binding of CPZ to hemoglobin was exothermic, whereas binding to myoglobin was endothermic with a high entropic contribution, suggesting that CPZ binding toMyoglobin is hydrophobic in nature.
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Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries.
TL;DR: The scientific rationale for the potential use of select phenothiazines for the management of pulmonary tuberculosis and malaria is presented.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Interaction of aminoacridines with deoxyribonucleic acid: Effects of ionic strength, denaturation, and structure
TL;DR: It is concluded that exact and complete intercalation is not a necessary condition of strong binding and that other, less regular, models, in which the positive ring nitrogens of the acridines are close to the DNA phosphates and the acbridine rings partially interact with the DNA base rings, are probably more consistent with the effect of denaturation of DNA on the binding curves which are characteristic of the interaction in solution.
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Kinetics of chlorpromazine cation radical decomposition in aqueous buffers
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Photomutagenesis by chlorinated phenothiazine tranquilizers
TL;DR: It is demonstrated that chlorinated phenothiazine drugs can be photoactivated to mutagenic species, whereas the nonchlorinated analogues do not possess this characteristic.