Journal ArticleDOI
Is the application of platelet concentrates effective in the prevention and treatment of medication-related osteonecrosis of the jaw? A systematic review.
TLDR
Results are not sufficient to establish the effectiveness of APCs in the prevention and treatment of MRONJ, and Randomized controlled trials with large sample size are needed.Abstract:
The aim of this systematic review was to answer the question: Is the application of autologous platelet concentrates (APCs) effective in the prevention and treatment of medication-related osteonecrosis of the jaw (MRONJ)? A literature search of PubMed, Scopus, and Web of Science databases (articles published until June 30, 2019) was conducted, in accordance with the PRISMA statement, using search terms related to “platelet concentrate” and “osteonecrosis”. The Jadad scale was used to assess the quality of the articles. Fisher's exact test was used to evaluate eventual differences between groups. Of 594 articles, 43 were included in the review (8 for MRONJ prevention and 35 for MRONJ treatment). Out of a total of 1219 dental extractions recorded (786 with APCs), only 12 cases of MRONJ have been reported (1%), all in patients with a history of high-dose antiresorptive treatment, and regardless of the use of APCs (p = 0.7634). Regarding MRONJ treatment, there were no statistically significant differences in terms of improvement between APC application and surgical treatment alone (p = 0.0788). Results are not sufficient to establish the effectiveness of APCs in the prevention and treatment of MRONJ. Randomized controlled trials with large sample size are needed.read more
Citations
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Journal ArticleDOI
Dose-Dependent Effects of Zoledronic Acid on Human Periodontal Ligament Stem Cells: An In Vitro Pilot Study:
Anna Di Vito,Emanuela Chiarella,Francesco Baudi,P Scardamaglia,Alessandro Antonelli,D Giudice,Tullio Barni,Leonzio Fortunato,Amerigo Giudice +8 more
TL;DR: Chronic exposure to 1 μM ZOL induced significant reduction of osteogenic differentiation, while ZOL concentrations ≥1.5 μM are required to impair PDLSCs viability and induce apoptosis.
Journal ArticleDOI
Infection as an Important Factor in Medication-Related Osteonecrosis of the Jaw (MRONJ)
Sven Otto,Suad Aljohani,Riham Fliefel,Sara Ecke,Oliver Ristow,Egon Burian,Matthias Troeltzsch,Christoph Pautke,Michael Ehrenfeld +8 more
TL;DR: In this paper, a critical review was conducted to collect the most reliable evidence regarding the link between local infection and MRONJ pathogenesis, which indicated that infection seems to have a major role in the pathogenesis of the disease.
Journal ArticleDOI
Autologous platelet‐rich fibrin injections in the management of facial cutaneous sinus tracts secondary to medication‐related osteonecrosis of the jaw
Francesco Bennardo,Luigi Bennardo,Ester Del Duca,Cataldo Patruno,Leonzio Fortunato,Amerigo Giudice,Steven Paul Nisticò +6 more
TL;DR: The management of facial cutaneous sinus tracts secondary to MRONJ with autologous PRF injections to determine if PRF is a valid therapeutic option in dermatology is described.
Journal ArticleDOI
Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study.
Francesco Bennardo,Francesco Liborio,Selene Barone,Alessandro Antonelli,Caterina Buffone,Leonzio Fortunato,Amerigo Giudice +6 more
TL;DR: In this article, the authors compared platelet-rich fibrin (PRF) and triamcinolone acetonide (TA) injective therapies in patients with OLP.
Journal ArticleDOI
The Case of Medication-Related Osteonecrosis of the Jaw Addressed from a Pathogenic Point of View. Innovative Therapeutic Strategies: Focus on the Most Recent Discoveries on Oral Mesenchymal Stem Cell-Derived Exosomes.
Amerigo Giudice,Alessandro Antonelli,Emanuela Chiarella,Francesco Baudi,Tullio Barni,Anna Di Vito +5 more
TL;DR: The literature confirms that the combination of mesenchymal stem cells (MSCs), biomaterials and local biomolecules can support the regeneration/repair of different structures and introduces the oral tissues recognized as sources of MSCs.
References
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Journal ArticleDOI
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
Journal ArticleDOI
Assessing the quality of reports of randomized clinical trials : is blinding necessary?
Alejandro R. Jadad,R. A. Moore,Dawn Carroll,C. Jenkinson,David Reynolds,David J. Gavaghan,Henry J McQuay +6 more
TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
Journal ArticleDOI
American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.
Salvatore L. Ruggiero,Thomas B. Dodson,John Fantasia,Reginald Goodday,Tara Aghaloo,Bhoomi Mehrotra,Felice O'Ryan +6 more
TL;DR: The American Association of Oral and Maxillofacial Surgeons (AAOMS) developed guidelines for medication-related osteonecrosis of the jaw (MRONJ) in 2007 and 2009 as mentioned in this paper.
Journal ArticleDOI
Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).
TL;DR: This classification of the different platelet concentrates into four categories, depending on their leucocyte and fibrin content, should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques.
Journal ArticleDOI
Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing
Joseph Choukroun,Antoine Diss,Alain Simonpieri,Marie-Odile Girard,Christian Schoeffler,Steve L. Dohan,Anthony Dohan,Jaafar Mouhyi,D. Dohan +8 more
TL;DR: Investigation is made into the previously evaluated biology of PRF with the first established clinical results, to determine the potential fields of application for this biomaterial and to plan several future PRF applications, including plastic and bone surgery.
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