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Bente L. Langdahl
Researcher at Aarhus University Hospital
Publications - 283
Citations - 12740
Bente L. Langdahl is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Osteoporosis & Bone remodeling. The author has an hindex of 49, co-authored 248 publications receiving 10485 citations. Previous affiliations of Bente L. Langdahl include Aarhus University.
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Journal ArticleDOI
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada,Unnur Styrkarsdottir,Evangelos Evangelou,Yi-Hsiang Hsu,Emma L. Duncan,Evangelia E. Ntzani,Ling Oei,Omar M. E. Albagha,Najaf Amin,John P. Kemp,Daniel L. Koller,Guo Shuai Li,Ching-Ti Liu,Ryan L. Minster,Alireza Moayyeri,Liesbeth Vandenput,Dana Willner,Su-Mei Xiao,Laura M. Yerges-Armstrong,Hou-Feng Zheng,Nerea Alonso,Joel Eriksson,Candace M. Kammerer,Stephen Kaptoge,Paul Leo,Gudmar Thorleifsson,Scott Wilson,Scott Wilson,James F. Wilson,Ville Aalto,Ville Aalto,Markku Alen,Aaron K. Aragaki,Thor Aspelund,Zoe H. Dailiana,David Duggan,Melissa Nolan Garcia,Natalia Garcia-Giralt,Sylvie Giroux,Göran Hallmans,Lynne J. Hocking,L. B. Husted,Karen A. Jameson,Khusainova Ri,Ghi Su Kim,Charles Kooperberg,Theodora Koromila,Marcin Kruk,Marika Laaksonen,Andrea Z. LaCroix,Seung-Hun Lee,P. C. Leung,Joshua R. Lewis,Laura Masi,Simona Mencej-Bedrač,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Millan S. Patel,Janez Prezelj,Lynda M. Rose,Serena Scollen,Kristin Siggeirsdottir,Albert V. Smith,Olle Svensson,Stella Trompet,Olivia Trummer,Natasja M. van Schoor,Jean Woo,Kun Zhu,Susana Balcells,Maria Luisa Brandi,Brendan M. Buckley,Sulin Cheng,Claus Christiansen,Cyrus Cooper,George Dedoussis,Ian Ford,Morten Frost,Morten Frost,David Goltzman,Jesús González-Macías,Mika Kähönen,Magnus Karlsson,Elza Khusnutdinova,Jung-Min Koh,Panagoula Kollia,Bente L. Langdahl,William D. Leslie,Paul Lips,Östen Ljunggren,Roman S. Lorenc,Janja Marc,Dan Mellström,Barbara Obermayer-Pietsch,José M. Olmos,Ulrika Pettersson-Kymmer,David M. Reid,José A. Riancho,Paul M. Ridker,François Rousseau,P. Eline Slagboom,Nelson Ls Tang,Roser Urreizti,Wim Van Hul,Jorma Viikari,María T. Zarrabeitia,Yurii S. Aulchenko,Martha C. Castaño-Betancourt,Elin Grundberg,Elin Grundberg,Lizbeth Herrera,Thorvaldur Ingvarsson,Hrefna Johannsdottir,Tony Kwan,Rui Jian Li,Robert Luben,Carolina Medina-Gomez,Stefan T Palsson,Sjur Reppe,Jerome I. Rotter,Gunnar Sigurdsson,Joyce B. J. van Meurs,Dominique J. Verlaan,Frances M K Williams,Andrew R. Wood,Yanhua Zhou,Kaare M. Gautvik,Tomi Pastinen,Soumya Raychaudhuri,Soumya Raychaudhuri,Jane A. Cauley,Daniel I. Chasman,Graeme R. Clark,Steven R. Cummings,Patrick Danoy,Elaine M. Dennison,Richard Eastell,John A. Eisman,John A. Eisman,Vilmundur Gudnason,Albert Hofman,Rebecca D. Jackson,Graeme Jones,J. Wouter Jukema,Kay-Tee Khaw,Terho Lehtimäki,Yongmei Liu,Mattias Lorentzon,Eugene V. McCloskey,Braxton D. Mitchell,Kannabiran Nandakumar,Geoffrey C. Nicholson,Ben A. Oostra,Munro Peacock,Huibert A. P. Pols,Richard L. Prince,Olli T. Raitakari,Olli T. Raitakari,Ian R. Reid,John A Robbins,Philip N. Sambrook,Pak C. Sham,Alan R. Shuldiner,Frances A. Tylavsky,Cornelia M. van Duijn,Nicholas J. Wareham,L. Adrienne Cupples,Michael J. Econs,David M. Evans,Tamara B. Harris,Annie W.C. Kung,Bruce M. Psaty,Jonathan Reeve,Tim D. Spector,Elizabeth A. Streeten,M. Carola Zillikens,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Claes Ohlsson,David Karasik,J. Brent Richards,Matthew A. Brown,Kari Stefansson,Kari Stefansson,André G. Uitterlinden,Stuart H. Ralston,John P. A. Ioannidis,John P. A. Ioannidis,Douglas P. Kiel,Fernando Rivadeneira +190 more
TL;DR: Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
Journal ArticleDOI
Romosozumab in Postmenopausal Women with Low Bone Mineral Density
Michael R. McClung,Andreas Grauer,Steven Boonen,Michael A. Bolognese,Jacques P. Brown,Adolfo Diez-Perez,Bente L. Langdahl,Jean-Yves Reginster,Jose R. Zanchetta,Scott M. Wasserman,Leonid Katz,Judy Maddox,Y.-C. Yang,Cesar Libanati,Henry G. Bone +14 more
TL;DR: In postmenopausal women with low bone mass, romosozumab was associated with increased bone mineral density and bone formation and with decreased bone resorption.
Journal ArticleDOI
Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus
Aliya Khan,Archie Morrison,David A. Hanley,Dieter Felsenberg,Laurie K. McCauley,Felice O'Ryan,Ian R. Reid,Salvatore L. Ruggiero,Akira Taguchi,Sotirios Tetradis,Nelson B. Watts,Maria Luisa Brandi,Edmund Peters,Teresa Guise,Richard Eastell,Angela M. Cheung,Suzanne N Morin,Basel Masri,Cyrus Cooper,Cyrus Cooper,Sarah L. Morgan,Barbara Obermayer-Pietsch,Bente L. Langdahl,Rana Al Dabagh,K. Shawn Davison,David L. Kendler,George K.B. Sándor,Robert G. Josse,Mohit Bhandari,Mohamed El Rabbany,D. D. Pierroz,Riad A. Sulimani,Deborah P. Saunders,Jacques P. Brown,Juliet E. Compston +34 more
TL;DR: In those patients at high risk for the development of ONJ, including cancer patients receiving high‐dose BP or Dmab therapy, consideration should be given to withholding antiresorptive therapy following extensive oral surgery until the surgical site heals with mature mucosal coverage.
Journal ArticleDOI
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Hou-Feng Zheng,Vincenzo Forgetta,Yi-Hsiang Hsu,Yi-Hsiang Hsu,Karol Estrada,Alberto Roselló-Díez,Paul Leo,Chitra Lekha Dahia,Chitra Lekha Dahia,Kyung-Hyun Park-Min,Jonathan H Tobias,Charles Kooperberg,Aaron Kleinman,Unnur Styrkarsdottir,Ching-Ti Liu,Charlotta Uggla,Daniel S. Evans,Carrie M. Nielson,Klaudia Walter,Ulrika Pettersson-Kymmer,Shane A. McCarthy,Joel Eriksson,Tony Kwan,Mila Jhamai,Katerina Trajanoska,Yasin Memari,J L Min,Jie Huang,Petr Danecek,Beth Wilmot,Rui Li,Wen-Chi Chou,Lauren E. Mokry,Alireza Moayyeri,Alireza Moayyeri,Melina Claussnitzer,Chia-Ho Cheng,Warren A. Cheung,Carolina Medina-Gomez,Bing Ge,Shu Huang Chen,Kwangbom Choi,Ling Oei,James Fraser,Robert Kraaij,Matthew A. Hibbs,Matthew A. Hibbs,Celia L Gregson,Denis Paquette,Albert Hofman,Carl Wibom,Gregory J. Tranah,Mhairi Marshall,Brooke Gardiner,Katie Cremin,Paul L. Auer,Li Hsu,Susan M. Ring,Joyce Y. Tung,Gudmar Thorleifsson,A.W. Enneman,Natasja M. van Schoor,Lisette C. P. G. M. de Groot,Nathalie van der Velde,Beatrice Melin,John P. Kemp,John P. Kemp,Claus Christiansen,Adrian Sayers,Yanhua Zhou,Sophie Calderari,Jeroen van Rooij,Christopher S. Carlson,Ulrike Peters,Soizik Berlivet,Josée Dostie,André G. Uitterlinden,Stephen R. Williams,Charles R. Farber,Daniel Grinberg,Andrea Z. LaCroix,Jeffrey Haessler,Daniel I. Chasman,Franco Giulianini,Lynda M. Rose,Paul M. Ridker,John A. Eisman,John A. Eisman,John A. Eisman,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Xavier Nogués,Natalia Garcia-Giralt,Lenore Launer,V. Gudnason,Dan Mellström,Liesbeth Vandenput,Najaf Amin,Cornelia M. van Duijn,Magnus Karlsson,Östen Ljunggren,Olle Svensson,Göran Hallmans,François Rousseau,Sylvie Giroux,Johanne Bussiere,Pascal P. Arp,Fjorda Koromani,Richard L. Prince,Richard L. Prince,Joshua R. Lewis,Joshua R. Lewis,Bente L. Langdahl,A. Pernille Hermann,Jens Erik Beck Jensen,Stephen Kaptoge,Kay-Tee Khaw,Jonathan Reeve,Jonathan Reeve,Melissa M. Formosa,Angela Xuereb-Anastasi,Kristina Åkesson,Fiona E. McGuigan,Gaurav Garg,José M. Olmos,María T. Zarrabeitia,José A. Riancho,Stuart H. Ralston,Nerea Alonso,Xi Jiang,David Goltzman,Tomi Pastinen,Elin Grundberg,Dominique Gauguier,Eric S. Orwoll,David Karasik,George Davey-Smith,Albert V. Smith,Kristin Siggeirsdottir,Tamara B. Harris,M. Carola Zillikens,Joyce B. J. van Meurs,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Matthew T. Maurano,Nicholas J. Timpson,Nicole Soranzo,Richard Durbin,Scott Wilson,Scott Wilson,Scott Wilson,Evangelia E. Ntzani,Evangelia E. Ntzani,Matthew A. Brown,Kari Stefansson,Kari Stefansson,David A. Hinds,Tim D. Spector,L. Adrienne Cupples,Claes Ohlsson,Celia M. T. Greenwood,Rebecca D. Jackson,David W. Rowe,Cynthia A. Loomis,David M. Evans,David M. Evans,Cheryl L. Ackert-Bicknell,Alexandra L. Joyner,Emma L. Duncan,Emma L. Duncan,Douglas P. Kiel,Fernando Rivadeneira,J. Brent Richards,J. Brent Richards +174 more
TL;DR: Evidence is provided that low‐frequency non‐coding variants have large effects on BMD and fracture, thereby providing rationale for whole‐genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
Journal ArticleDOI
Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS.
Elena Tsourdi,Bente L. Langdahl,Martine Cohen-Solal,Bérengère Aubry-Rozier,Erik Fink Eriksen,Núria Guañabens,Barbara Obermayer-Pietsch,Stuart H. Ralston,Richard Eastell,M. Carola Zillikens +9 more
TL;DR: There appears to be an increased risk of multiple vertebral fractures after discontinuation of denosumab although strong evidence for such an effect and for measures to prevent the occurring bone loss is lacking.