Journal ArticleDOI
Kinetic and Equilibrium Studies on the Role of the β-147 Histidine in the Root Effect and Cooperativity in Carp Hemoglobin
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This article is published in Biochemistry.The article was published on 1983-01-01. It has received 42 citations till now. The article focuses on the topics: Cooperativity & Root effect.read more
Citations
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Journal ArticleDOI
Species adaptation in a protein molecule.
TL;DR: The results indicate that the tertiary and quaternary structures of deoxy- and oxyhemoglobin have remained almost invariant during vertebrate evolution and that most of the amino acid replacements between species are functionally neutral.
Book ChapterDOI
1 Hemoglobin Structure and Function
TL;DR: This chapter describes the hemoglobin (Hb) structure and function in fishes and finds that the fixed acid Haldane effect is generally large in teleosts, but differs among species.
Book ChapterDOI
The Physiology of the Root Effect
Bernd Pelster,Roy E. Weber +1 more
TL;DR: In 1931 Root reported that the presence of CO2 markedly reduced the oxygen content of the blood of toadfish, sea robin, and mackerel and caused the oxygen dissociation curve of the hemoglobin to become “nearly asymptotic with respect to the abscissa before saturation is complete”, which is still a valid description of the Root effect.
Journal ArticleDOI
The Root effect
TL;DR: The physiological role of Root effect haemoglobins is demonstrably not inevitably linked to the swim bladder but more probably arose from the need to oxygenate the poorly vascularized retina of many fishes.
Journal ArticleDOI
Evolution of vertebrate haemoglobins : Histidine side chains, specific buffer value and Bohr effect
TL;DR: The analysis predicts that teleost fishes, passeriform birds and some snakes have independently evolved a much-reduced specific buffer value of Hb, possibly for enhancing the efficiency of an acid load to change oxygen affinity via the Bohr effect.
References
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Journal ArticleDOI
On the Nature of Allosteric Transitions: A Plausible Model
TL;DR: "It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."
Journal ArticleDOI
A Rapidly Convergent Descent Method for Minimization
Roger Fletcher,M. J. D. Powell +1 more
TL;DR: A number of theorems are proved to show that it always converges and that it converges rapidly, and this method has been used to solve a system of one hundred non-linear simultaneous equations.
Book ChapterDOI
Analytical gel chromatography of proteins.
TL;DR: This chapter describes the fundamental aspects of gel chromatography as they comprise a set of analytical techniques that a protein chemist may use, and it is evident that the group of techniques based on the partitioning of molecules into porous gel networks constitutes an extremely versatile and useful array of analytical tools for the studies of protein systems.
Journal ArticleDOI
Identification of residues responsible for the alkaline Bohr effect in haemoglobin.
TL;DR: The imidazole groups of the C-terminal histidines of the β-chains, together with the α-amino groups ofThe α- chains, are responsible for most of the Bohr effect.
Journal ArticleDOI
Stereochemistry of cooperative effects in fish and amphibian haemoglobins
Max F. Perutz,Maurizio Brunori +1 more
TL;DR: A stereochemical model for the binding of the allosteric effectors ATP or GTP is advanced and shows that hydrogen bonds between this serine and the C-terminal histidine stabilize the quaternary deoxy(T) structure.
Related Papers (5)
Stereochemistry of cooperative effects in fish and amphibian haemoglobins
Max F. Perutz,Maurizio Brunori +1 more