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Open AccessJournal ArticleDOI

Kinetics of hemoglobin and transition state theory

Attila Szabo
- 01 May 1978 - 
- Vol. 75, Iss: 5, pp 2108-2111
TLDR
It is shown that the qualitative differences in the kinetics of NO, O2, CO, and bulky isocyanides can be understood in structural terms in a framework based on transition state theory.
Abstract
Experimental evidence indicates that the way cooperativity in hemoglobin is manifested kinetically depends on the nature of the ligand. It is shown that the qualitative differences in the kinetics of NO, O2, CO, and bulky isocyanides can be understood in structural terms in a framework based on transition state theory.

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Citations
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Journal ArticleDOI

Funnels, pathways, and the energy landscape of protein folding: A synthesis

TL;DR: The work unifies several previously proposed ideas concerning the mechanism protein folding and delimits the regions of validity of these ideas under different thermodynamic conditions.
Book ChapterDOI

Sickle cell hemoglobin polymerization.

TL;DR: The chapter discusses the thermodynamic and kinetic studies of solutions, and includes a description of the nonideal behavior of concentrated hemoglobin S solutions and the effects of physiologically relevant variables, especially oxygen, and the presence of non-S hemoglobins on the polymerization process.
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Mechanisms of Cooperativity and Allosteric Regulation in Proteins

TL;DR: Allosteric membrane proteins are studied as indicators of allosteric equilibrium on spin state and coordination of the haem iron and of feedback inhibition without change of quaternary structure in E. Coli repressors.
Journal ArticleDOI

Geminate recombination of carbon monoxide to myoglobin

TL;DR: Comparison of the two results using the simplest kinetic model suggests that the 30-fold more rapid overall association rate for the reaction of oxygen with myoglobin compared to carbon monoxide results mainly from faster binding at the heme, with a small contribution from more rapid entry of oxygen into the protein from the solvent.
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