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This article is published in Clinical Infectious Diseases.The article was published on 2022-08-17 and is currently open access. It has received 5 citations till now. The article focuses on the topics: Medicine & Betacoronavirus.read more
Citations
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Familial hypercholesterolemia: The nexus of endothelial dysfunction and lipoprotein metabolism in COVID-19
TL;DR: In this paper , the authors found that patients with heterozygous familial hypercholesterolemia (HeFH) are at increased risk for COVID-19 cardiovascular complications in the acute phase of the infection.
Journal ArticleDOI
Familial hypercholesterolemia: The nexus of endothelial dysfunction and lipoprotein metabolism in COVID-19
TL;DR: In this paper , the authors found that patients with heterozygous familial hypercholesterolemia (HeFH) are at increased risk for COVID-19 cardiovascular complications in the acute phase of the infection.
Journal ArticleDOI
Reply to Chen et al; Uchikoba et al; Siberry et al; and Vuorio et al.
Journal ArticleDOI
Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms.
Laura Kate Gadanec,Kristen Renee McSweeney,Peter Kubatka,Martin Caprnda,Ludovit Gaspar,Robert Prosecky,Jozef Dragašek,Peter Kruzliak,Vasso Apostolopoulos,Anthony Zulli +9 more
TL;DR: In this paper , an isometric tension analysis was conducted on 18-week-old male C57BL/6 mice (n = 4) brachiocephalic arteries (BC), iliac arteries (IL), and abdominal (AA) and thoracic aorta (TA).
References
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Journal ArticleDOI
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TL;DR: Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)
Posted ContentDOI
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Dafydd R. Owen,Charlotte Moira Norfor Allerton,Annaliesa S. Anderson,Lisa Aschenbrenner,Melissa Avery,Simon Berritt,Britton Boras,Rhonda D. Cardin,Anthony Carlo,Karen J. Coffman,Alyssa Dantonio,Li Di,Heather Eng,RoseAnn Ferre,Ketan S. Gajiwala,Scott A. Gibson,Samantha Elizabeth Greasley,Brett L. Hurst,Eugene P. Kadar,Amit S. Kalgutkar,Jack C. Lee,Jisun Lee,Wei Liu,Stephen W. Mason,Stephen Noell,Jonathan J. Novak,R. Scott Obach,Kevin Ogilvie,Nandini Chaturbhai Patel,Martin Pettersson,Devendra K. Rai,Matthew R. Reese,Matthew F. Sammons,Jean G. Sathish,Ravi Shankar P. Singh,Claire M. Steppan,Al E. Stewart,Jamison B. Tuttle,Lawrence W. Updyke,Patrick Robert Verhoest,Liuqing Wei,Qingyi Yang,Yuao Zhu +42 more
TL;DR: The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS-CoV-2) has become a global pandemic as discussed by the authors.
Journal ArticleDOI
Statins and the Covid-19 main protease: In silico evidence on direct interaction
Željko Reiner,Mahdi Hatamipour,Maciej Banach,Maciej Banach,Matteo Pirro,Khalid Al-Rasadi,Tannaz Jamialahmadi,Dina Radenkovic,Fabrizio Montecucco,Amirhossein Sahebkar +9 more
TL;DR: Results indicate that statins could be efficient SARS-CoV-2 Mpro inhibitors, based upon the binding energy of pitavastatin, rosuvastsatin, lovastatin and fluvastatin; however, further research is necessary to investigate their potential use as drugs for COVID-19.
Journal ArticleDOI
Effectiveness of Paxlovid in Reducing Severe Coronavirus Disease 2019 and Mortality in High-Risk Patients
R. Najjar-Debbiny,Naomi Gronich,Gabriel Weber,Johad Khoury,Maisam Amar,Nili Stein,Lee E. Goldstein,Walid Saliba +7 more
TL;DR: Paxlovid appears to be more effective in older patients, immunosuppressed patients, and patients with underlying neurological or cardiovascular disease and in real-life settings, Paxlovid is highly effective in reducing the risk of severe COVID-19 or mortality.
Journal ArticleDOI
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Jan Wenzel,Josephine Lampe,Helge Müller-Fielitz,Raphael Schuster,Marietta Zille,Kristin Müller,Markus Krohn,Jakob Körbelin,Linlin Zhang,Umit Ozorhan,Vanessa Neve,Julian U. G. Wagner,Denisa Bojkova,Mariana Shumliakivska,Yun Jiang,Anke Fähnrich,Fabian Ott,Valentin Sencio,Cyril Robil,Susanne Pfefferle,Florent Sauve,Caio Coelho,Jonas Franz,Jonas Franz,Frauke Spiecker,Beate Lembrich,Sonja Binder,Nina Feller,Peter König,Hauke Busch,Ludovic Collin,Roberto Villaseñor,Olaf Jöhren,Hermann C. Altmeppen,Manolis Pasparakis,Stefanie Dimmeler,Jindrich Cinatl,Klaus Püschel,Matija Zelic,Dimitry Ofengeim,Christine Stadelmann,François Trottein,Rubén Nogueiras,Rolf Hilgenfeld,Markus Glatzel,Vincent Prevot,Markus Schwaninger +46 more
TL;DR: In this article, structural changes in cerebral small vessels of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models were investigated.
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