Open AccessJournal Article
Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma.
Reinier O. Schlingemann,F.J.R. Rietveld,R. M. W. De Waal,N. J. Bradley,A. I. Skene,A. J. S. Davies,M. F. Greaves,J. Denekamp,Dirk J. Ruiter +8 more
TLDR
Findings suggest that CD34 is an endothelial marker for EAM present during angiogenesis, and is preferentially found on a small subset of cells with the morphologic appearance of migrating cells.About:
This article is published in Laboratory Investigation.The article was published on 1990-06-01 and is currently open access. It has received 205 citations till now. The article focuses on the topics: Angiogenesis & Endothelium.read more
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Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors
Shunichi Morikawa,Peter Baluk,Toshiyuki Kaidoh,Amy Haskell,Rakesh K. Jain,Donald M. McDonald +5 more
TL;DR: It is concluded that pericytes are present on most tumor vessels but have multiple abnormalities, including altered expression of marker proteins, which raises the possibility of an involvement in sprout growth or retraction in tumors.
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Vascular endothelial growth factors and angiogenesis in eye disease.
TL;DR: Recent findings that VEGFs secreted by epithelia, including the retinal pigment epithelium (RPE), are likely to mediate paracrine vascular survival signals for adjacent endothelia may explain the pathogenesis of subretinal neovascularisation in AMD.
Journal Article
Angiogenesis: Potentials for Pharmacologic Intervention in the Treatment of Cancer, Cardiovascular Diseases, and Chronic Inflammation
TL;DR: The potentials, limitations, and challenges within this field of research are discussed, in light of the development of new therapeutic strategies for diseases in which angiogenesis plays an important role.
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Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer.
Elizabeth Horak,N. Klenk,Russell Leek,Susan LeJeune,Kenneth G. C. Smith,N. Stuart,Adrian L. Harris,Michael Greenall,Kasia Stepniewska +8 more
TL;DR: The results suggest that angiogenesis is closely linked to metastasis, that it is acquired at a critical density of vessels, and that this process occurs as tumours enlarge or become more poorly differentiated.
Journal ArticleDOI
Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation
P. E. Vermeulen,Giampietro Gasparini,Stephen B. Fox,Masakazu Toi,L. Martin,Peter McCulloch,Francesco Pezzella,Giuseppe Viale,Noel Weidner,Adrian L. Harris,Luc Dirix +10 more
TL;DR: ‘Angiogenesis Group, Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Belgium'; ‘ICRF Molecular Oncologists, University of Oxford, Oxford, U.K.