Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes.
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TLDR
Results indicate that the apolipoprotein A-I/C-III/A-IV multigene family was established before mammalian radiation and suggest that these genes are similarly organized in the genomes of all mammals.About:
This article is published in Journal of Biological Chemistry.The article was published on 1986-10-05 and is currently open access. It has received 184 citations till now. The article focuses on the topics: Gene & Complementary DNA.read more
Citations
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Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
Bart Staels,Ngoc Vu-Dac,V. A. Kosykh,Régis Saladin,Jean-Charles Fruchart,Jean Dallongeville,Johan Auwerx +6 more
TL;DR: It is demonstrated that fibrates decrease rat and human liver apo C-III gene expression at the transcriptional level, and may contribute to the hypotriglyceridemic action of these drugs.
Journal ArticleDOI
Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily
TL;DR: The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis.
Journal ArticleDOI
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.
TL;DR: A functional consequence of the promiscuous DNA binding of COUP-TF is its ability to down-regulate hormonal induction of target gene expression by other members of the steroid-thyroid hormone receptor superfamily such as the vitamin D3, thyroid hormone, and retinoic acid receptors.
Journal ArticleDOI
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Steven A. Kliewer,Kazuhiko Umesono,Richard A. Heyman,David J. Mangelsdorf,Jacqueline A. Dyck,Ronald M. Evans +5 more
TL;DR: The retinoid X receptor (RXR) and COUP-TF bind preferentially to a DR-1 motif, and these results support a general proposal in which the half-site spacing preferences may be used as a means to decipher potentially complex and interactive regulatory circuits.
Journal ArticleDOI
Cholesterol metabolism in neurons and astrocytes
Frank W. Pfrieger,Nicole Ungerer +1 more
TL;DR: An understanding of cholesterol metabolism in the brain and its role in disease requires a close look at individual cell types, including neurons and astrocytes, which are identified as net producers and consumers of cholesterol.
References
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TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
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Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
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