Journal ArticleDOI
Lipidated proteins: Spotlight on protein-membrane binding interfaces.
TLDR
This review demonstrates the potential of regulating lipid modifications that are essential for cell survival and discusses the concepts regarding their role in disease and therapeutics.Abstract:
The covalent attachment of lipids to proteins is a fundamental property of all living cells. These lipidated or lipid-modified proteins are directly targeted to the membranes and display diverse functional roles that are critical to cell function such as membrane signaling and trafficking. All lipidated proteins have been classified by the type of chemical moieties that are attached to them mainly palmitoylation, myristoylation, prenylation, cholesterylation, and addition of the Glycosylphosphatidyl inositol (GPI) anchor. Although the distinct hydrophobic lipid moiety largely dictates the functional compartmentalization, it also facilitates membrane trafficking and triggers a wide range of signaling pathways in cellular growth. In this review, we will focus on mechanistic insights underlying their membrane attachment, with a view to understand the regions that contribute to protein-membrane interface specificity. We also present a computational case study to report how different membrane lipids modulate insertion of the lipidated LC3 protein. Finally, in this review, we demonstrate the potential of regulating lipid modifications that are essential for cell survival and we discuss the concepts regarding their role in disease and therapeutics.read more
Citations
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Journal ArticleDOI
Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Melanie P. Muller,Melanie P. Muller,Tao Jiang,Chang Sun,Muyun Lihan,Shashank Pant,Paween Mahinthichaichan,Anda Trifan,Emad Tajkhorshid +8 more
TL;DR: A broad survey of MD simulations focusing on exploring lipid-protein interactions and characterizing lipid-modulated protein structure and dynamics that have been successful in providing novel insight into the mechanism of membrane protein function is provided.
Journal ArticleDOI
Plant lipids: Key players of plasma membrane organization and function.
Adiilah Mamode Cassim,Paul Gouguet,Julien Gronnier,Nelson Laurent,Véronique Germain,Magali S. Grison,Yohann Boutté,Patricia Gerbeau-Pissot,Françoise Simon-Plas,Sébastien Mongrand +9 more
TL;DR: How lipids are key players in the function of PM in plants, with a particular focus on plant-microbe interaction, transport and hormone signaling, abiotic stress responses, plasmodesmata function is discussed.
Journal ArticleDOI
Divide and Rule: Plant Plasma Membrane Organization.
Julien Gronnier,Julien Gronnier,Patricia Gerbeau-Pissot,Véronique Germain,Sébastien Mongrand,Françoise Simon-Plas +5 more
TL;DR: Listing and linking recent progress in precisely qualifying these heterogeneities will help to draw an integrated picture of the plant PM, and contribute to deciphering the crucial role of the PM in cell physiology.
Journal ArticleDOI
Lipids at membrane contact sites: cell signaling and ion transport.
TL;DR: Several aspects of MCSs are discussed in the context of lipid transfer, formation of lipid domains, generation of Ca2+ and cAMP second messengers, and regulation of ion transporters by lipids.
Journal ArticleDOI
GPS-Palm: a deep learning-based graphic presentation system for the prediction of S-palmitoylation sites in proteins.
TL;DR: This work compiled a benchmark data set containing 3098 known S-palmitoylation sites identified from small- or large-scale experiments, and developed a new method named DQD to distinguish data quality weights (DQWs) between the two types of the sites, and designed a new predictor called GPS-Palm.
References
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Journal ArticleDOI
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TL;DR: The emphasis in this review is on the enzymology of prenyl protein processing and the functional significance ofPrenylation in cellular events.
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