Liver Involvement Associated with Dengue Infection in Adults in Vietnam
Le Thi Thu Thao,Tran Tinh Hien,Nguyen Ngoc Vinh,Pham Tran Dieu Hien,Nguyen Tran Chinh,Nguyen Tran Chinh,Cameron P. Simmons,Bridget Wills,Bridget Wills +8 more
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TLDR
The spectrum and evolution of disease manifestations among 644 adults with d Dengue who were prospectively recruited on admission to a major infectious disease hospital in southern Vietnam are described and a group of patients with similar illnesses not caused by dengue is compared.Abstract:
Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children. We describe the spectrum and evolution of disease manifestations among 644 adults with dengue who were prospectively recruited on admission to a major infectious disease hospital in southern Vietnam and compare them with a group of patients with similar illnesses not caused by dengue. Transaminase levels increased in virtually all dengue patients and correlated with other markers of disease severity. However, peak enzyme values usually occurred later than other complications. Clinically severe liver involvement was infrequent and idiosyncratic, but usually resulted in severe bleeding. Chronic co-infection with hepatitis B was associated with modestly but significantly increased levels of alanine aminotransferase, but did not otherwise impact the clinical picture.read more
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Economic and Disease Burden of Dengue in Southeast Asia
TL;DR: Dengue poses a substantial economic and disease burden in Southeast Asia with a DALY burden per million inhabitants in the region higher than that of 17 other conditions, including Japanese encephalitis, upper respiratory infections, and hepatitis B.
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The pathogenesis of dengue.
TL;DR: This review summarises recent developments in the understanding of d Dengue pathogenesis and their relevance to dengue vaccine development.
Journal ArticleDOI
Dengue and its effects on liver.
Jayanta Samanta,Vishal Sharma +1 more
TL;DR: The present review focuses on the hepatic manifestations and the pathogenesis of the liver injury in dengue.
Journal ArticleDOI
Patterns and causes of liver involvement in acute dengue infection
Samitha Fernando,Ananda Wijewickrama,Laksiri Gomes,C Punchihewa,S. D. P. Madusanka,Harsha Dissanayake,Chandima Jeewandara,Hemantha Peiris,Graham S. Ogg,Gathsaurie Neelika Malavige,Gathsaurie Neelika Malavige +10 more
TL;DR: Dengue associated liver injury appears to peak around day 6 and 7 of illness, and liver function tests done at earlier dates might not reflect the extent of liver involvement in acute infection.
References
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Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.
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Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
TL;DR: Three examples of emerging and resurging diseases of global significance are described: the resurgence of dengue in tropical and subtropical areas of the world, and the spread and establishment of Japanese encephalitis and West Nile viruses in new habitats and environments.
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Dengue haemorrhagic fever: diagnosis, treatment, prevention and control
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AASLD position paper : the management of acute liver failure
Julie Polson,William M. Lee +1 more
TL;DR: This document has been designated as a Position Paper, since the topic contains more data based on expert opinion than on randomized controlled trials and is thus not considered to have the emphasis and certainty of a Practice Guideline.
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Early Clinical and Laboratory Indicators of Acute Dengue Illness
Siripen Kalayanarooj,David W. Vaughn,S. Nimmannitya,Sharone Green,Saroj Suntayakorn,N. Kunentrasai,W. Viramitrachai,S. Ratanachu-eke,S. Kiatpolpoj,Bruce L. Innis,Alan L. Rothman,A. Nisalak,Francis A. Ennis +12 more
TL;DR: Simple clinical and laboratory parameters are identified that help to identify children with DF or DHF, including plasma AST levels were higher in children who developed DHF than in those with DF.
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