Localization of the Putative Sialic Acid-binding Site on the Immunoglobulin Superfamily Cell-surface Molecule CD22
TLDR
The results provide further evidence that immunoglobulin superfamily cell adhesion molecules use the GFCC′C″ β-sheet of membrane-distal V-set domains to bind structurally diverse ligands, suggesting that this surface is favored for cell-cell recognition.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-04-19 and is currently open access. It has received 141 citations till now. The article focuses on the topics: Sialoadhesin & Sialic acid binding.read more
Citations
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Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition.
Halina Lis,Nathan Sharon +1 more
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Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
Takashi Angata,Ajit Varki +1 more
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Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
TL;DR: Advances in experimental design and data analysis methods are making it possible to accurately define the assembly mechanisms and rate constants associated with macromolecular interactions.
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Siglecs--the major subfamily of I-type lectins.
Ajit Varki,Takashi Angata +1 more
TL;DR: Siglecs as mentioned in this paper is a family of I-type lectins with sialic acid (Sia)-binding properties and characteristic amino-terminal structural features, which appear to have evolved by convergent evolution.
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Multifarious roles of sialic acids in immunity
Ajit Varki,Pascal Gagneux +1 more
TL;DR: This overview surveys examples of biological roles of sialic acids in immunity, with emphasis on an evolutionary perspective, given the breadth of the subject.
References
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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
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Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
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The Immunoglobulin Superfamily—Domains for Cell Surface Recognition
and A F Williams,A N Barclay +1 more
TL;DR: The domain hypothesis was firmly established when the structures of V and C domains were determined to reveal a common fold forming a sandwich of two p-sheets that was stabilized by the conserved disulfide bond.
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A hot spot of binding energy in a hormone-receptor interface
Tim Clackson,James A. Wells +1 more
TL;DR: The x-ray crystal structure of the complex between human growth hormone and the extracellular domian of its first bound receptor (hGHbp) shows that about 30 side chains from each protein make contact, which resembles a cross section through a globular protein.
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pEF-BOS, a powerful mammalian expression vector.
TL;DR: The pEFBOS vector will be used to produce a large amount of growth factors and proteins in mammalian cells, to express a high level of anti-sense RNA, and will be an ideal positive control for CAT assay in various cell types.