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Journal ArticleDOI

Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis

TLDR
Low-dose budesonide is more effective than placebo in maintaining EoE in histologic and clinical remission and signs of esophageal remodeling showed a trend toward normalization.
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This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2011-05-01. It has received 332 citations till now. The article focuses on the topics: Eosinophilic esophagitis & Budesonide.

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Journal ArticleDOI

Epidemiology and Natural History of Eosinophilic Esophagitis

TL;DR: The data and potential reasons behind this increase, risk factors, and important areas for research into disease etiology are reviewed, as well as the progression of EoE from an inflammatory to fibrostenotic phenotype.
Journal ArticleDOI

A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease

TL;DR: In this large EoE cohort, the likelihood of fibrostenotic disease increased markedly with age, and this association suggests that the natural history of Eosinophilic esophagitis is a progression from an inflammatory to a fibrostanotic disease.
References
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Journal ArticleDOI

Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.

TL;DR: A multidisciplinary task force of 31 physicians assembled with the goal of determining diagnostic criteria and making recommendations for evaluation and treatment of children and adults with suspected eosinophilic esophagitis (EE) provided current recommendations for care of affected patients.
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Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

TL;DR: It is shown that lipopolysaccharide from Gram-negative bacteria activates interleukin-5 (IL-5)- or interferon-γ–primed eosinophils to release mitochondrial DNA in a reactive oxygen species–dependent manner, but independent of eosInophil death, suggesting a previously undescribed mechanism of eOSinophil-mediated innate immune responses that might be crucial for maintaining the intestinal barrier function after inflammation-associated epithelial cell damage
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Esophageal Eosinophilia with Dysphagia A Distinct Clinicopathologic Syndrome

TL;DR: The presence of high concentrations of IEE in esophageal biopsies from patients with dysphagia, normal endoscopy, and normal 24-hr esophagal pH monitoring represents a distinctive clinicopathologic syndrome not previously described.
Journal ArticleDOI

Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years

TL;DR: Eosinophilic esophagitis, a primary and chronic disease restricted to the esophagus, leads to persistent dysphagia and structural esophageal alterations but does not impact the nutritional state.
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