Journal ArticleDOI
Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis
Alex Straumann,Sébastien Conus,Lukas Degen,Cornelia Frei,Christian Bussmann,Christoph Beglinger,Alain M. Schoepfer,Hans-Uwe Simon +7 more
TLDR
Low-dose budesonide is more effective than placebo in maintaining EoE in histologic and clinical remission and signs of esophageal remodeling showed a trend toward normalization.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2011-05-01. It has received 332 citations till now. The article focuses on the topics: Eosinophilic esophagitis & Budesonide.read more
Citations
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Journal ArticleDOI
ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE)
Evan S. Dellon,Nirmala Gonsalves,Ikuo Hirano,Glenn T. Furuta,Chris A. Liacouras,David A. Katzka +5 more
TL;DR: Recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of patients with eosinophilic–esophageal disorders.
Journal ArticleDOI
Food allergy: a practice parameter update-2014.
Hugh A. Sampson,Seema S. Aceves,S. Allan Bock,John M. James,Stacie M. Jones,David M. Lang,Kari C. Nadeau,Anna Nowak-Wegrzyn,John Oppenheimer,Tamara T. Perry,Christopher Randolph,Scott H. Sicherer,Ronald A. Simon,Brian P. Vickery,Robert J. Wood,David I. Bernstein,Joann Blessing-Moore,David A. Khan,Richard A. Nicklas,Jay M. Portnoy,Diane E. Schuller,Sheldon L. Spector,Stephen A. Tilles,Dana Wallace +23 more
TL;DR: This parameter was developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allerg, Acetiology & Infectious Diseases (ACAAI); and the Joint Council of Allergic, Aceto-Allergy, Immunology and Immunology(JCAAI) as discussed by the authors.
Journal ArticleDOI
Epidemiology and Natural History of Eosinophilic Esophagitis
Evan S. Dellon,Ikuo Hirano +1 more
TL;DR: The data and potential reasons behind this increase, risk factors, and important areas for research into disease etiology are reviewed, as well as the progression of EoE from an inflammatory to fibrostenotic phenotype.
Journal ArticleDOI
World Gastroenterology Organisation Global Guidelines: probiotics and prebiotics October 2011.
Francisco Guarner,Aamir G. Khan,James Garisch,Rami Eliakim,Alfred Gangl,Alan Thomson,Justus Krabshuis,Ton Lemair,Pedro Kaufmann,Juan Andres de Paula,Richard N. Fedorak,Fergus Shanahan,Mary Ellen Sanders,Hania Szajewska,Balakrishnan S. Ramakrishna,Tarkan Karakan,Nayoung Kim +16 more
TL;DR: Review Team: Juan-R.
Journal ArticleDOI
A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
Evan S. Dellon,Hannah P. Kim,Sarah L.W. Sperry,David A. Rybnicek,John T. Woosley,Nicholas J. Shaheen +5 more
TL;DR: In this large EoE cohort, the likelihood of fibrostenotic disease increased markedly with age, and this association suggests that the natural history of Eosinophilic esophagitis is a progression from an inflammatory to a fibrostanotic disease.
References
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Journal ArticleDOI
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.
Glenn T. Furuta,Chris A. Liacouras,Margaret H. Collins,Sandeep K. Gupta,Chris Justinich,Phil E. Putnam,Peter A Bonis,Eric Hassall,Alex Straumann,Marc E. Rothenberg +9 more
TL;DR: A multidisciplinary task force of 31 physicians assembled with the goal of determining diagnostic criteria and making recommendations for evaluation and treatment of children and adults with suspected eosinophilic esophagitis (EE) provided current recommendations for care of affected patients.
Journal ArticleDOI
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
Shida Yousefi,Jeffrey A. Gold,Nicola Andina,James J. Lee,Ann M. Kelly,Evelyne Kozlowski,Inès Schmid,Alex Straumann,Janine Reichenbach,Gerald J. Gleich,Hans-Uwe Simon +10 more
TL;DR: It is shown that lipopolysaccharide from Gram-negative bacteria activates interleukin-5 (IL-5)- or interferon-γ–primed eosinophils to release mitochondrial DNA in a reactive oxygen species–dependent manner, but independent of eosInophil death, suggesting a previously undescribed mechanism of eOSinophil-mediated innate immune responses that might be crucial for maintaining the intestinal barrier function after inflammation-associated epithelial cell damage
Journal ArticleDOI
Eosinophilic Esophagitis: A 10-Year Experience in 381 Children
Chris A. Liacouras,Chris A. Liacouras,Jonathan M. Spergel,Eduardo Ruchelli,Ritu Verma,Ritu Verma,Maria R. Mascarenhas,Maria R. Mascarenhas,Edisio Semeao,Edisio Semeao,Jonathan Flick,Jonathan Flick,Janice A. Kelly,Janice A. Kelly,Terry Brown–Whitehorn,Petar Mamula,Petar Mamula,Jonathan E. Markowitz,Jonathan E. Markowitz +18 more
TL;DR: Medications such as corticosteroids are effective; however, upon withdrawal, EoE recurs, and the removal of dietary antigens significantly improved clinical symptoms and esophageal histology in 98% of patients.
Journal ArticleDOI
Esophageal Eosinophilia with Dysphagia A Distinct Clinicopathologic Syndrome
TL;DR: The presence of high concentrations of IEE in esophageal biopsies from patients with dysphagia, normal endoscopy, and normal 24-hr esophagal pH monitoring represents a distinctive clinicopathologic syndrome not previously described.
Journal ArticleDOI
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
Alex Straumann,Hans-Peter Spichtin,Leticia Grize,Kathleen A. Bucher,Christoph Beglinger,Hans-Uwe Simon +5 more
TL;DR: Eosinophilic esophagitis, a primary and chronic disease restricted to the esophagus, leads to persistent dysphagia and structural esophageal alterations but does not impact the nutritional state.
Related Papers (5)
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Chris A. Liacouras,Glenn T. Furuta,Ikuo Hirano,Dan Atkins,Stephen Attwood,Peter A Bonis,A. Wesley Burks,Mirna Chehade,Margaret H. Collins,Evan S. Dellon,Ranjan Dohil,Gary W. Falk,Nirmala Gonsalves,Sandeep K. Gupta,David A. Katzka,Alfredo J. Lucendo,Jonathan E. Markowitz,Richard J. Noel,Robert D. Odze,Philip E. Putnam,Joel E. Richter,Yvonne Romero,Eduardo Ruchelli,Hugh A. Sampson,Alain M. Schoepfer,Nicholas J. Shaheen,Scott H. Sicherer,Stuart J. Spechler,Jonathan M. Spergel,Alex Straumann,Barry K. Wershil,Marc E. Rothenberg,Seema S. Aceves +32 more