Journal ArticleDOI
Long-term follow-up of chronic hepatitis B patients treated with interferon alfa
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Contrary to reports from Western countries, complete elimination of markers of hepatitis B virus infection was uncommon in Chinese patients with chronic hepatitis B who underwent interferon therapy despite similar duration of follow-up.About:
This article is published in Gastroenterology.The article was published on 1993-12-01. It has received 196 citations till now. The article focuses on the topics: Hepatitis B virus & Interferon alfa.read more
Citations
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Journal ArticleDOI
Hepatitis B virus infection.
TL;DR: This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new treatments capable of eradicating chronic infection.
Journal ArticleDOI
Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
Journal ArticleDOI
Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
Journal ArticleDOI
Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B
George K. K. Lau,Teerha Piratvisuth,Kang Xian Luo,Patrick Marcellin,Satawat Thongsawat,Graham Cooksley,Edward Gane,Michael W. Fried,Wan Cheng Chow,Seung Woon Paik,Wen Yu Chang,Thomas Berg,Robert Flisiak,Philip McCloud,Nigel Pluck +14 more
TL;DR: In patients with H beAg-positive chronic hepatitis B, peginterferon alfa-2a offers superior efficacy over lamivudine, on the basis of HBeAg seroconversion, HBV DNA suppression, and HBsAg serconversion.
Journal ArticleDOI
Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B.
Claus Niederau,Tobias Heintges,Stefan Lange,Georg Goldmann,Christoph M. Niederau,Leonhard Mohr,Dieter Häussinger +6 more
TL;DR: In patients with chronic hepatitis B infection, the clearance of HBeAg after treatment with interferon alfa is associated with improved clinical outcomes, and overall survival and survival without clinical complications were significantly longer in patients who were seronegative for H beAg after therapy withInterferonAlfa.
References
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Journal Article
初期食道静脈りゅう治療におけるテルイプレシン(グリプレシン)とバソプレシンの比較試験
Journal ArticleDOI
Randomized, controlled trial of recombinant human α-interferon in patients with chronic hepatitis B
Jay H. Hoofnagle,Jay H. Hoofnagle,Marion G. Peters,Marion G. Peters,Kevin D. Mullen,Kevin D. Mullen,D. Brian Jones,D. Brian Jones,Vinod K. Rustgi,Vinod K. Rustgi,Adrian M. Di Bisceglie,Adrian M. Di Bisceglie,Claire W. Hallahan,Claire W. Hallahan,Yoon Park,Yoon Park,Carlton Meschievitz,Carlton Meschievitz,E. Anthony Jones,E. Anthony Jones +19 more
TL;DR: It is indicated that a 4-mo course of recombinant alpha-interferon can induce a remission in disease in approximately one-third of patients with chronic hepatitis B.
Journal ArticleDOI
Long-term remission of chronic hepatitis B after alpha-interferon therapy.
J. Korenman,B. Baker,Jeanne G. Waggoner,James E. Everhart,A. M. Di Bisceglie,Jay H. Hoofnagle +5 more
TL;DR: Remissions in chronic hepatitis B induced by alpha-interferon are of long duration and are followed, in most patients, by the loss of HBsAg and all evidence of residual virus replication.
Journal ArticleDOI
Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: A prospective study
TL;DR: The results suggest that the incidence of delayed clearance of HBsAg during chronic HBV infection is low and HBeAg status, age of patients and development of cirrhosis are determinants forHBsAg clearance.
Journal ArticleDOI
A controlled trial of interferon with or without prednisone priming for chronic hepatitis B
Anna S.F. Lok,Pui Chee Wu,Ching-Lung Lai,Johnson Y.N. Lau,Elsie K.Y. Leung,Loretta S.K. Wong,Oliver C.K. Ma,Ian J. Lauder,Clara P.L. Ng,Hau Tim Chung +9 more
TL;DR: It was confirmed that Chinese patients with normal transaminase levels respond very poorly to interferon alfa therapy, but the response was significantly better in patients with elevated transaminases levels.
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Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B.
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Robert P. Perrillo,Eugene R. Schiff,Gary L. Davis,Henry C. Bodenheimer,Karen L. Lindsay,John A. Payne,Jules L. Dienstag,Christopher B. O'Brien,Carlo H. Tamburro,Ira M. Jacobson,Richard E. Sampliner,David Feit,Jay H. Lefkowitch,Mary C. Kuhns,Carlton Meschievitz,Bharati Sanghvi,Janice K. Albrecht,Alexandra L. Gibas +17 more