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Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran

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TLDR
Research in Ramsar, a northern coastal city of Iran, has some high level natural radiation areas (HLNRAs) as well as over 50 hot springs with low and high radium contents used as spas by the public and vacationers, and shows significant increase of CD69 expression on TCD4+ stimulated cells and total serum IgE and higher incidence of stable and unstable chromosomal aberrations in the HLNRA group compared to the control group with normal background radiation.
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This article is published in Journal of Environmental Radioactivity.The article was published on 2004-01-01. It has received 60 citations till now. The article focuses on the topics: Population & Environmental exposure.

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ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context

TL;DR: Estimates of ‘practical’ threshold doses for tissue injury defined at the level of 1% incidence are provided and it appears that the rate of dose delivery does not modify the low incidence for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease.

ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs -- threshold doses for tissue reactions in a radiation protection context

TL;DR: In this paper, the authors present a statement on the early and late effects of ionising radiation in normal tumor and kidney responses to irradiation, as well as some modifications of normal tumor response.
Journal ArticleDOI

Human exposure to high natural background radiation: what can it teach us about radiation risks?

TL;DR: The possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation is reviewed.
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Radioadaptive response revisited.

TL;DR: Although adaptive response seems to function by an on/off principle, it is a phenomenon showing a high degree of inter- and intraindividual variability, it remains to be seen to what extent adaptive response is functional in humans at relevant dose and dose-rate exposures.
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Anti-inflammatory effects of low-dose radiotherapy. Indications, dose, and radiobiological mechanisms involved.

TL;DR: In this paper, a review of the most effective low-dose radiotherapy treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies is presented.
References
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Cancer Mortality in the High Background Radiation Areas of Yangjiang, China during the Period between 1979 and 1995

TL;DR: The mortality of all cancers in HBRA was generally lower than that in the control area, but not statistically significant, and neither homogeneity tests nor trend tests revealed any statistically significant relationship between cancer risk and radiation dose.
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Down's syndrome and related abnormalities in an area of high background radiation in coastal Kerala

TL;DR: The view that radiation-induced genetic anomalies occur with above average frequency in the population living in the area with high background radiation is supported.
Journal Article

Regulation of Homocytotropic Antibody Formation in the Rat: VIII. An Antigen-Specific T Cell Factor That Regulates anti-Hapten Homocytotropic Antibody Response

TL;DR: Results suggest that the inhibitory cell interaction in the rat HTA formation, which has previously been reported by us, is mediated by this subcellular component of primed T cell which is not immunoglobulin in nature but has an affinity and specificity to the carrier molecule.
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Genetic Monitoring of the Human Population from High-Level Natural Radiation Areas of Kerala on the Southwest Coast of India. II. Incidence of Numerical and Structural Chromosomal Aberrations in the Lymphocytes of Newborns'

TL;DR: A striking observation was the presence of rogue cells, the rarely occurring metaphases with a high level of chromosomal damage, which have not been reported previously among newborns, which are comparable between the high-level and normal-level natural radiation areas.
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Dose-effect Relationship of Dicentric and Ring Chromosomes in Lymphocytes of Individuals Living in the High Background Radiation Areas in China

TL;DR: The frequency of Dic + Rc linearly increases over lifetime due to chronic low dose exposure and it is likely that the activation of repair enzymes is not triggered in the present HBRA, and Threshold dose of the induction of chromosome aberrations, if any, is below the present dose level.
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