Journal ArticleDOI
Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran
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TLDR
Research in Ramsar, a northern coastal city of Iran, has some high level natural radiation areas (HLNRAs) as well as over 50 hot springs with low and high radium contents used as spas by the public and vacationers, and shows significant increase of CD69 expression on TCD4+ stimulated cells and total serum IgE and higher incidence of stable and unstable chromosomal aberrations in the HLNRA group compared to the control group with normal background radiation.About:
This article is published in Journal of Environmental Radioactivity.The article was published on 2004-01-01. It has received 60 citations till now. The article focuses on the topics: Population & Environmental exposure.read more
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ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context
F A Stewart,A V Akleyev,Martin Hauer-Jensen,Jolyon H Hendry,N J Kleiman,Thomas J. MacVittie,B M Aleman,Angela B. Edgar,K Mabuchi,C R Muirhead,Roy E. Shore,William Wallace +11 more
TL;DR: Estimates of ‘practical’ threshold doses for tissue injury defined at the level of 1% incidence are provided and it appears that the rate of dose delivery does not modify the low incidence for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease.
ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs -- threshold doses for tissue reactions in a radiation protection context
C. H. Clement,F. A. Stewart +1 more
TL;DR: In this paper, the authors present a statement on the early and late effects of ionising radiation in normal tumor and kidney responses to irradiation, as well as some modifications of normal tumor response.
Journal ArticleDOI
Human exposure to high natural background radiation: what can it teach us about radiation risks?
Jolyon H Hendry,Steven L. Simon,Andrzej Wojcik,Mehdi Sohrabi,Werner Burkart,Elisabeth Cardis,Dominique Laurier,Margot Tirmarche,Isamu Hayata,Isamu Hayata +9 more
TL;DR: The possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation is reviewed.
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Radioadaptive response revisited.
Soile Tapio,Vesna Jacob +1 more
TL;DR: Although adaptive response seems to function by an on/off principle, it is a phenomenon showing a high degree of inter- and intraindividual variability, it remains to be seen to what extent adaptive response is functional in humans at relevant dose and dose-rate exposures.
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Anti-inflammatory effects of low-dose radiotherapy. Indications, dose, and radiobiological mechanisms involved.
Meritxell Arenas,Sebastià Sabater,Vicent Hernandez,Angels Rovirosa,Pedro C. Lara,Alberto Biete,Julián Panés +6 more
TL;DR: In this paper, a review of the most effective low-dose radiotherapy treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies is presented.
References
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IL-4-based helper activity of CD4+ T cells is radiation sensitive☆
TL;DR: The sensitivity of T helper cells with regard to the induction of IgE but not IgG synthesis was due to the sensitivity to irradiation of the production of IL-4 but not ofIL-2, consistent with observations thatIL-4 and IL-5 synthesis in such cells was greatly diminished by irradiation, whereas IL-2 synthesis was only minimally affected.
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Gamma radiation induces CD69 expression on lymphocytes.
TL;DR: CD69 functions as a marker for response to radiation, but unlike antigen or mitogen, radiation-induced CD69 expression does not lead to proliferation.
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The cellular lesion responsible for exaggerated IgE synthesis accompanying allergic breakthrough
TL;DR: It is concluded that this functional subset of CD4+ T cells, which normally controls CD8+ T cell activity in this network, is defective in animals that exhibit irradiation-induced allergic breakthrough.
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New immunomodulator lobenzarit disodium (CCA): activation of IgE class-specific suppressor T lymphocytes and regulation of IgE antibody response enhanced by sublethal X-irradiation in SJL/J mice.
TL;DR: CCA-induced reduction of IgE antibody response in SJL/J mice seems to be mediated by suppressor T cells, since depletion of T cells by treatment with antithymocyte serum and complement abolished the CCA- induced reduction and splenic T cells from CCA treated mice were able to transfer the suppressive effect.