Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice.
Gaiqing Wang,Gaiqing Wang,Anatol Manaenko,Anwen Shao,Yi-bo Ou,Peng Yang,Enkhjargal Budbazar,Derek Nowrangi,John H. Zhang,Jiping Tang +9 more
TLDR
The use of low-density lipoprotein receptor-related protein-1 as supplement provides a novel approach to ameliorating intracerebral hemorrhage brain injury via its pleiotropic neuroprotective effects.Citations
More filters
Journal ArticleDOI
Haemoglobin scavenging in intracranial bleeding: biology and clinical implications.
Diederik Bulters,Ben Gaastra,Ardalan Zolnourian,Sheila Alexander,Dianxu Ren,Spiros Blackburn,Mark K. Borsody,Sylvain Doré,James Galea,Koji Iihara,Paul A. Nyquist,Ian Galea +11 more
TL;DR: A consensus opinion on the research priorities that will help to bring about clinical benefits for patients with intracranial bleeding is presented, and an improved basic scientific understanding of the mechanism of haemoglobin toxicity and its clearance from the brain is considered.
Journal ArticleDOI
Brain iron overload following intracranial haemorrhage
TL;DR: Important components of normal brain iron homeostasis are summarised and the existing evidence on iron-related brain injury mechanisms is analyzed and treatment options of particular promise are discussed.
Journal ArticleDOI
LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats.
Jianhua Peng,Jinwei Pang,Lei Huang,Budbazar Enkhjargal,Tongyu Zhang,Jun Mo,Pei Wu,Weilin Xu,Yuchun Zuo,Jun Peng,Gang Zuo,Ligang Chen,Jiping Tang,John H. Zhang,Yong Jiang +14 more
TL;DR: The LRP1 activation attenuated WMI and improved neurological function by modulating M2 microglial polarization at least in part through Shc1/PI3K/Akt signaling in a rat model of SAH is investigated and the apoE-mimic peptide COG1410 may serve as a promising treatment in the management ofSAH patients.
Journal ArticleDOI
Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice.
Tian Wang,Tian Wang,Derek Nowrangi,Lingyan Yu,Tai Lu,Jiping Tang,Bing Han,Yu-Xin Ding,Fenghua Fu,John H. Zhang +9 more
TL;DR: DRD1 activation by A68930 improves neurological outcome through inhibition of NLRP3-mediated inflammation in ICH mice and reversed effects of A68928 on neurological outcome and brain edema.
Journal ArticleDOI
Hematoma clearance as a therapeutic target in intracerebral hemorrhage: From macro to micro.
TL;DR: Despite the absence of an intervention shown to improve outcomes in intracerebral hemorrhage, preclinical work has led to a greater understanding of the pathologic pathways of brain injury.
References
More filters
Journal ArticleDOI
Mechanisms of brain injury after intracerebral haemorrhage
TL;DR: The coagulation cascade, haemoglobin breakdown products, and inflammation all play a part in ICH-induced injury and could provide new therapeutic targets and new therapeutic interventions for this severe form of stroke.
Journal ArticleDOI
Free heme toxicity and its detoxification systems in human
Sanjay Kumar,Uday Bandyopadhyay +1 more
TL;DR: Free heme acts as a pro-inflammatory molecule and heme-induced inflammation is involved in the pathology of diverse conditions; such as renal failure, arteriosclerosis, and complications after artificial blood transfusion, peritoneal endometriosis, and heart transplant failure.
Journal ArticleDOI
Molecular Pathophysiology of Cerebral Hemorrhage Secondary Brain Injury
Jaroslaw Aronowski,Xiurong Zhao +1 more
TL;DR: In this paper, the authors discuss the relevance of hematoma resolution processes as a target for ICH therapy and present potential clinically relevant molecular targets that could be harnessed to treat secondary injury associated with ICH injury.
Journal ArticleDOI
LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies
TL;DR: Tissue-specific gene deletion studies reveal an important contribution of LRP1 in the vasculature, central nervous system, macrophages, and adipocytes, revealing a critical, but as of yet, undefined role in development.
Journal ArticleDOI
Inflammation after Intracerebral Hemorrhage
Jian Wang,Sylvain Doré +1 more
TL;DR: In this review, a summary of the available literature on the inflammatory responses after ICH is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies.
Related Papers (5)
Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
Richard F. Keep,Ya Hua,Guohua Xi +2 more
Molecular Pathophysiology of Cerebral Hemorrhage Secondary Brain Injury
Jaroslaw Aronowski,Xiurong Zhao +1 more