Low Vitamin D Status despite Abundant Sun Exposure
Neil Binkley,Rachel Novotny,Diane Krueger,Tisha N. Kawahara,Yihe G. Daida,Gary L. Lensmeyer,Bruce W. Hollis,Marc K. Drezner +7 more
TLDR
Data suggest that variable responsiveness to UVB radiation is evident among individuals, causing some to have low vitamin D status despite abundant sun exposure, and it seems prudent to use this value as an upper limit when prescribing vitamin D supplementation.Abstract:
Context: Lack of sun exposure is widely accepted as the primary cause of epidemic low vitamin D status worldwide. However, some individuals with seemingly adequate UV exposure have been reported to have low serum 25-hydroxyvitamin D [25(OH)D] concentration, results that might have been confounded by imprecision of the assays used. Objective: The aim was to document the 25(OH)D status of healthy individuals with habitually high sun exposure. Setting: This study was conducted in a convenience sample of adults in Honolulu, Hawaii (latitude 21°). Participants: The study population consisted of 93 adults (30 women and 63 men) with a mean (sem) age and body mass index of 24.0 yr (0.7) and 23.6 kg/m2 (0.4), respectively. Their self-reported sun exposure was 28.9 (1.5) h/wk, yielding a calculated sun exposure index of 11.1 (0.7). Main Outcome Measures: Serum 25(OH)D concentration was measured using a precise HPLC assay. Low vitamin D status was defined as a circulating 25(OH)D concentration less than 30 ng/ml. Re...read more
Citations
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Is vitamin D deficiency a major global public health problem
TL;DR: A more recent systematic review of global vitamin D status, with particular emphasis in at risk groups, concluded that vitamin D deficiency is a global public health problem in all age groups, particularly in those from the Middle East.
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The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement
Clifford J. Rosen,John S. Adams,Daniel D. Bikle,Dennis M. Black,Marie B. Demay,JoAnn E. Manson,M. Hassan Murad,Christopher S. Kovacs +7 more
TL;DR: More studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.
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Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica
John Brehm,Juan C. Celedón,Manuel E. Soto-Quiros,Lydiana Avila,Gary M. Hunninghake,Erick Forno,Daniel Laskey,Jody S. Sylvia,Bruce W. Hollis,Scott T. Weiss,Augusto A. Litonjua +10 more
TL;DR: The results suggest that vitamin D insufficiency is relatively frequent in an equatorial population of children with asthma and in these children, lower vitamin D levels are associated with increased markers of allergy and asthma severity.
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Vitamin D and diabetes: let the sunshine in.
TL;DR: The evidence relative to the impact of vitamin D in the development of diabetes, metabolic syndrome, and diabetes complications is assessed and the assessment and suggested treatment for vitamin D deficiency is addressed.
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Is vitamin D deficiency to blame for the asthma epidemic
TL;DR: Providing adequate vitamin D supplementation in pregnancy may lead to significant decreases in asthma incidence in young children, and this has been associated with obesity, African American race, and recent immigrants to westernized countries, thus reflecting the epidemiologic patterns observed in the asthma epidemic.
References
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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Journal ArticleDOI
Origins and evolution of the Western diet: health implications for the 21st century
Loren Cordain,S. Boyd Eaton,Anthony Sebastian,Neil Mann,Staffan Lindeberg,Bruce A. Watkins,James H. O'Keefe,Janette C. Brand-Miller +7 more
TL;DR: The evolutionary collision of the authors' ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization.
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Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic Implications
TL;DR: Vitamin D3 is recommended in housebound elderly, and it may be cost-effective in hip fracture prevention in selected risk groups, and vitamin D3 supplementation may decrease the incidence of hip and other peripheral fractures in nursing home residents.
Journal ArticleDOI
Estimates of optimal vitamin D status
Bess Dawson-Hughes,Robert P. Heaney,Michael F. Holick,Paul Lips,Pierre J. Meunier,Reinhold Vieth,Reinhold Vieth +6 more
TL;DR: Based on the available evidence, it is believed that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
Journal ArticleDOI
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
TL;DR: Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.