Journal ArticleDOI
Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism.
J Bas,Màtil Calopa,Mariona Mestre,David G. Molleví,Blanca Cutillas,Santiago Ambrosio,Enric Buendia +6 more
TLDR
In this article, the involvement of the immune system in Parkinson's disease was assessed using the phenotype of circulating lymphocytes in 30 untreated and 34 treated patients, and they found a numeric decrease in helper T cells (higher in CD4+CD45RA(+) than in CD+CD29(+)) and B cells, and a rise in activated, CD4(+)CD25(+) lymphocytes that was correlated with lymphocyte depletion.About:
This article is published in Journal of Neuroimmunology.The article was published on 2001-02-01. It has received 224 citations till now. The article focuses on the topics: Parkinsonism & Lymphocyte.read more
Citations
More filters
Journal ArticleDOI
Neuroinflammation in Parkinson's disease: a target for neuroprotection?
TL;DR: Overall, available data support the importance of non-cell-autonomous pathological mechanisms in Parkinson's disease, which are mostly mediated by activated glial and peripheral immune cells.
Journal ArticleDOI
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Tony Wyss-Coray,Lennart Mucke +1 more
TL;DR: Since many inflammatory responses are beneficial, directing and instructing the inflammatory machinery may be a better therapeutic objective than suppressing it.
Journal ArticleDOI
Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients
Steve Horvath,Beate Ritz +1 more
TL;DR: Overall, this study shows that the epigenetic age of the immune system is significantly increased in PD patients and that granulocytes play a significant role.
Journal ArticleDOI
Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease
R. Lee Mosley,Eric J. Benner,Irena Kadiu,Mark P. Thomas,Michael D. Boska,Khader M. Hasan,Chad Laurie,Howard E. Gendelman +7 more
TL;DR: Research from others and their own laboratories seek to harness such inflammatory processes with the singular goal of developing therapeutic interventions that positively affect the tempo and progression of human disease.
Journal ArticleDOI
Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease.
TL;DR: It is shown for the first time that adoptive transfer of CD3‐activated Tregs to MPTP‐intoxicated mice provides greater than 90% protection of the nigrostriatal system through modulation of microglial oxidative stress and inflammation.
References
More filters
Journal ArticleDOI
Parkinsonism: Onset, progression, and mortality
Margaret M. Hoehn,Melvin D. Yahr +1 more
TL;DR: Controversy over the effectiveness of therapeutic measures for parkinsonism is due partially to this wide variability and to the paucity of clinical information about the natural history of the syndrome.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
Journal ArticleDOI
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases.
TL;DR: Multiple epidemiological studies indicate that patients taking anti-inflammatory drugs or suffering from conditions in which such drugs are routinely used, have a decreased risk of developing Alzheimer disease.
Journal ArticleDOI
Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients
Makio Mogi,Minoru Harada,Tomoyshi Kondo,Peter Riederer,Hirofumi Inagaki,Masayasu Minami,Toshiharu Nagatsu +6 more
TL;DR: The present results suggest that the concentrations of IL-1 beta, IL-6, EGF, and TGF-alpha in the dopaminergic, striatal regions were significantly higher in parkinsonian patients than those in controls, whereas those in the cerebral cortex did not show significant differences between parkinsonians and control subjects.
Journal ArticleDOI
Criteria for diagnosing Parkinson's disease.
TL;DR: This work proposes the following designated levels of confidence for the diagnosis of Parkinson's disease in its initial phases of clinical expression: (1) clinically possible, (2) clinically probable, and (3) clinically definite.