Lymphocytic Thyroiditis on Histology Correlates with Serum Thyroglobulin Autoantibodies in Patients with Papillary Thyroid Carcinoma: Impact on Detection of Serum Thyroglobulin
Francesco Latrofa,Debora Ricci,Lucia Montanelli,Roberto Rocchi,Paolo Piaggi,Eleonora Sisti,Lucia Grasso,Fulvio Basolo,Clara Ugolini,Aldo Pinchera,Paolo Vitti +10 more
TLDR
In papillary thyroid carcinoma, LT on histology must be carefully searched for because it is frequently associated with TgAb and therefore mistakenly low or undetectable Tg, which can be underestimated in patients with T g autoantibodies (TgAb).Abstract:
Context: Serum thyroglobulin (Tg), the marker of residual tumor in papillary thyroid carcinoma, can be underestimated in patients with Tg autoantibodies (TgAb) TgAb are due to a coexistent lymphocytic thyroiditis (LT) or the papillary thyroid carcinoma per se TgAb assays are highly discordant Design: We evaluated 141 patients with a clinical diagnosis of nodular thyroid disease, 32 of Hashimoto's thyroiditis, and four of Graves' disease, who underwent total thyroidectomy for an associated papillary thyroid carcinoma Patients were classified as papillary thyroid carcinoma-lymphocytic thyroiditis (PTC-T) and papillary thyroid carcinoma (PTC) according to the presence or absence of LT on histology Tg was measured before thyroid remnant ablation, when it is expectedly detectable, by an immunometric assay (IMA) and TgAb by three noncompetitive IMA and three competitive radioimmunoassays (RIA) The number of lymphocytes was compared with TgAb concentration Results: Seventy-two of 177 patients (407%) wereread more
Citations
More filters
Journal ArticleDOI
Lymphocytic thyroiditis is associated with increased number of benign cervical nodes and fewer central neck compartment metastatic lymph nodes in patients with differentiated thyroid cancer
TL;DR: Lymphocytic thyroiditis is associated with fewer central neck compartment metastatic lymph nodes and a larger number of excised reactive benign cervical lymph nodes, which indicates a protective role of thyroid autoimmunity in lymph node spreading remains unclear.
Journal ArticleDOI
Thyroid Nodules and Thyroid Cancer in the Pregnant Woman.
TL;DR: The comprehensive evaluation of thyroid nodules during pregnancy includes a medical history, physical examination, ultrasound assessment, and an ultrasound-guided fine-needle aspiration biopsy.
Journal ArticleDOI
Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods.
Federica D'Aurizio,Paolo Metus,Anna Ferrari,Benedetta Caruso,Roberto Castello,Danilo Villalta,Agostino Steffan,K. Gaspardo,F. Pesente,Nicola Bizzaro,Elio Tonutti,S. Valverde,Chiara Cosma,Mario Plebani,Renato Tozzoli +14 more
TL;DR: TgAb URL should be used with caution in the management of differentiated thyroid carcinoma patients since the presence and/or the degree of TgAb interference in Tg measurement has not yet been well defined.
Journal ArticleDOI
Preoperative serum thyroglobulin predicts initial distant metastasis in patients with differentiated thyroid cancer.
Hosu Kim,Hosu Kim,Young Nam Kim,Hye In Kim,So-Young Park,Jun-Ho Choe,Jung-Han Kim,Jee Soo Kim,Jae Hoon Chung,Tae Hyuk Kim,Sun Wook Kim +10 more
TL;DR: Preoperative Tg levels were useful for predicting initial DM of DTC, and measurement of serum Tg in patients with DTC may guide preoperative staging evaluation and initial treatment.
Journal ArticleDOI
Surgical options for thyroid cancer and post-surgical management.
TL;DR: It is important for providers to recognize that the short and long-term follow up must be guided by surveillance studies, and patients need to be re-risk stratified in order to optimize detection of recurrence yet sustain quality of life.
References
More filters
Journal ArticleDOI
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Bryan R. Haugen,Erik K. Alexander,Keith C. Bible,Gerard M. Doherty,Susan J. Mandel,Yuri E. Nikiforov,Furio Pacini,Gregory W. Randolph,Anna M. Sawka,Martin Schlumberger,Kathryn G. Schuff,Steven I. Sherman,Julie Ann Sosa,David L. Steward,R. Michael Tuttle,Leonard Wartofsky +15 more
TL;DR: Evidence-based recommendations are developed to inform clinical decision-making in the management of thyroid nodules and differentiated thyroid cancer and represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
David S. Cooper,Gerard M. Doherty,Bryan R. Haugen,Richard T. Kloos,Stephanie L. Lee,Susan J. Mandel,Ernest L. Mazzaferri,Bryan McIver,Furio Pacini,Martin Schlumberger,Steven I. Sherman,David L. Steward,R. Michael Tuttle +12 more
TL;DR: Evidence-based recommendations in response to the appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
Increasing incidence of thyroid cancer in the United States, 1973-2002.
Louise Davies,H. Gilbert Welch +1 more
TL;DR: In this article, the authors examined trends in thyroid cancer incidence, histology, size distribution, and mortality in the United States, concluding that the increasing incidence of thyroid cancer is primarily due to the increased detection of small papillary cancers.
Journal ArticleDOI
European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
Furio Pacini,Martin Schlumberger,Henning Dralle,Rossella Elisei,Johannes W. A. Smit,Wilmar M. Wiersinga +5 more
TL;DR: European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium Furio Pacini, Martin Schlumberger, Henning Dralle, Rossella Elisei, Johannes W A Smit, Wilmar Wiersinga and the European Thyroid Cancer Taskforce Section of Endocrinology and Metabolism are presented.
Journal ArticleDOI
Papillary and follicular thyroid carcinoma.
TL;DR: Treatment of recurrences is based mainly on surgery and 131I treatment, and the recent availability of recombinant human thyroid stimulating hormone has greatly improved the quality of the patient's life during follow-up.