Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma
Silvia Mannucci,Stefano Tambalo,Giamaica Conti,Leonardo Ghin,Alessio Milanese,Anna Carboncino,Elena Nicolato,Maria Rosaria Marinozzi,Donatella Benati,Roberto Bassi,Pasquina Marzola,Andrea Sbarbati +11 more
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TLDR
It is suggested that naturally synthesized magnetosomes could be effectively considered as theranostic agent candidates for hyperthermia based on iron oxide nanoparticles because of their high transversal relaxivity.Abstract:
Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacteria: magnetosomes The efficacy of such protocol is tested in a xenograft model of glioblastoma Mice receive a single intratumoral injection of magnetosomes, and they are exposed three times in a week to an alternating magnetic field with concurrent temperature measurements MRI is used to visualize the nanoparticles and to monitor tumor size before and after the treatment Statistically significant inhibition of the tumor growth is detected in subjects exposed to the alternating magnetic field compared to control groups Moreover, thanks to magnetosomes high transversal relaxivity, their effective delivery to the tumor tissue is monitored by MRI It is apparent that the efficacy of this protocol is limited by inhomogeneous delivery of magnetosomes to tumor tissue These results suggest that naturally synthesized magnetosomes could be effectively considered as theranostic agent candidates for hyperthermia based on iron oxide nanoparticlesread more
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Radiomics in medical imaging-"how-to" guide and critical reflection.
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Applications of Magnetotactic Bacteria, Magnetosomes and Magnetosome Crystals in Biotechnology and Nanotechnology: Mini-Review.
Gabriele Vargas,Jefferson Cypriano,Tarcisio Correa,Pedro Leão,Dennis A. Bazylinski,Fernanda Abreu +5 more
TL;DR: Metric analysis using Scopus and Web of Science databases from 2003 to 2018 showed that applied research involving magnetite from MTB in some form has been focused mainly in biomedical applications, particularly in magnetic hyperthermia and drug delivery.
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Microbe-Mediated Extracellular and Intracellular Mineralization: Environmental, Industrial, and Biotechnological Applications
TL;DR: The different types of microbe‐mediated biomineralization that occur in nature, their mechanisms, as well as their applications are elucidated to create a backdrop for future research.
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Magnetic Fluid Hyperthermia Based on Magnetic Nanoparticles: Physical Characteristics, Historical Perspective, Clinical Trials, Technological Challenges, and Recent Advances
Hossein Etemadi,Paul G. Plieger +1 more
TL;DR: In this article, the physical mechanisms behind heat dissipation by magnetic nanoparticles (MNPs) that instigate cell death pathways are discussed, as well as recent technological progress in the field toward the advancement of MFH.
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Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles
Wenhui Ling,Mingyu Wang,Chunxia Xiong,Dengfeng Xie,Qiyu Chen,Xinyue Chu,Xiaoyan Qiu,Yuemin Li,Xiong Xiao +8 more
TL;DR: In this paper, a review of six main approaches for the synthesis of magnetic iron oxide nanoparticles (MIONPs), surface modification of MIONPs with inorganic materials, organic molecules, and polymer molecules, applications and technical challenges of synthesizing MIONP, and their limitations in biomedical applications are described.
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